Lipidhydrolyse

The underlying molecular mechanism leading to peroxisomal dysfunction in the absence of functional ABHD5/CGI-58 is poorly understood. PP13 investigates the consequences of ABHD5 deficiency on peroxisomal β-oxidation of fatty acids and the generation of fatty alcohols essential for ether lipid and wax ester synthesis. PP13 will elucidate the role of ABHD5 in the peroxisomal transport of fatty acids and examine whether mutant variants of ABHD5 known to cause neutral lipid storage disease with ichthyosis affect peroxisome metabolism and aims to identify and characterize putative lipid hydrolases, especially in the skin. PP13 will assess the cause and consequences of defective FA metabolism in skin of mice and human epidermal equivalents with keratinocytes deficient in ABHD5.

Principal Investigator

Priv.-Doz. Mag. Dr.rer.nat
Franz Radner 
T: +43 316 380 1921

Team

Members

  • Sandra Alohan, PhD student, Understanding the role of ultra-long chain triacylglycerol estolides in skin integrity and barrier formation
  • Nadine Egger, PhD student, Unravelling the role of ABHD5 in peroxisome metabolism
  • Margaritha Schratter, PhD student, The Functional Role of NIPAL4 in the Formation of the Skin Permeability Barrier (associated)