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Metabolism and Circulation research fieldResearch fieldsMedical University of Graz

Research

We engage in cutting-edge research in the field of metabolism and circulation and put our basic research findings into practice in clinical trials. Our targeted translational research is based on expertise and interaction with many different specialists.

Current research projects

Doctoral College Metabolic and Cardiovascular Disease (DK-MCD)

  • DK-MCD
  • is a PhD educational program that deals with molecular mechanisms and cellular functions in the pathogenesis of metabolic and cardiovascular diseases. DK-MCD fosters multidisciplinary faculty and (inter)national student exchange in the field of metabolic and cardiovascular diseases from basic research to clinical practice. In DK-MCD, our team investigates the consequences of missing lipases in different organs and cells on lipid and energy metabolism in various model organisms.
  • Project duration: 2010–2022
  • Funded by: FWF, Med Uni Graz
  • Project partners: Dagmar Kratky, Gerald Höfler, Wolfgang Graier, Klaus Groschner, Peter Fickert, Martin Pichler (Med Uni Graz), Günter Hämmerle, Frank Madeo (Uni Graz), Ruth Birner-Grünberger (TU Wien)

doc.fund (BioMolStruct)

  • In the international PhD educational program BioMolStruct, we have assembled a unique group of researchers from three universities in Graz. Our program addresses the growing demand for scientists in integrative structural biology. Our young researchers investigate biomolecules and biomolecular complexes that play essential roles in signaling and cellular metabolism. The emphasis is on biomolecules connected to aging, cancer and neurodegenerative, metabolic and cardiovascular diseases. BioMolStruct junior researchers are prepared to master future challenges in biomedical fields of research with in-depth knowledge and innovative methods.
  • Project duration: 2021–2024
  • Funded by: FWF, Med Uni Graz, Uni Graz, TU Graz, federal state of Styria
  • Project partners: Tobias Madl, Ruth Prassl (MedUni Graz); Karl Gruber, Walter Keller, Monika Oberer, Georg Pabst, Tea Pavkov-Keller, Klaus Zangger (Uni Graz); Gustav Oberdorfer, Andreas Winkler (TU Graz)

doc.fund Inflammatory Disorders in Pregnancy (DP-iDP)

  • In the PhD educational program DP-iDP, thirteen research teams apply a variety of approaches to the methodical analysis of the interaction between pregnancy, inflammation and the placenta in maternal and fetal diseases. Our team investigates the role of intracellular lipid hydrolases in the lipid and energy metabolism of the placenta and fetus in mice. We pursue the hypothesis that the loss of these enzymes results in fewer fatty acids and signal molecules, influencing the metabolism in the placenta and fetus and causing changes in cells and tissue.
  • Project duration: 2018–2022
  • Funded by: FWF, Med Uni Graz
  • Project partners: Gernot Desoye, Martin Gauster, Daniela Gold, Akos Heinemann, Ursula Hiden, Berthold Huppertz, Julia Kargl, Dagmar Kratky, Gunther Marsche, Karoline Mayer-Pickel, Christine Moissl-Eichinger, Christian Wadsack (Med Uni Graz), Mireille van Poppel (Uni Graz)

doc.fund (RESPImmun)

  • The PhD educational program RESPImmun concentrates on lung diseases and immunomodulatory mechanisms that are critical to medical research and patient care. RESPImmun is a demanding program that delivers the highest level of doctoral education. A unique feature is its translational and interdisciplinary character, which unites specialists from various disciplines: pneumology, pathology, immunology, pharmacology, translational sciences, molecular biology and bioinformatics. Knowledge and concepts are combined in order to inform students of the connection between chronic lung diseases, which promotes an understanding of the underlying pathologies.
  • Project duration: 2021–2024
  • Funded by: FWF, Med Uni Graz
  • Project partners: Akos Heinemann, Gerald Höfler, Julia Kargl, Grazyna Kwapiszewska, Katharina Leithner, Gunther Marsche, Leigh Marsh, Christine Moissl-Eichinger, Andrea Olschewski, Horst Olschewski, Herbert Strobl, Eva Sturm, Peter Tomazic

SFB Lipid Hydrolysis: Cellular (patho)mechanisms of lipid degradation

  • The SFB consortium pursues the following project goals: (1) discover and determine the biochemical character of unknown lipid hydrolases, (2) explain the function of known and new lipid hydrolases, (3) describe the complex reaction processes of hydrolysis of lipids and (4) investigate the role of lipid hydrolases in the origin of diseases such as obesity, diabetes, nonalcoholic fatty liver disease or cancer. Our findings should also contribute to the development of new treatment options for the world's most common health problems.
  • Project duration: 2019–2023
  • Funded by: FWF, Med Uni Graz, federal state of Styria, City of Graz
  • Project partners: Dagmar Kratky (Med Uni Graz), Günter Hämmerle, Monika Oberer, Rudolf Zechner, Robert Zimmermann (Uni Graz), Ruth Birner-Grünberger (TU Wien), Michael Trauner (Med Uni Wien)

Our research achievements

Projects

Research projects conducted within the research field
Forschungsprojekte

Publications

Scientific publications within the research field
Publikationen