Diagnostik- und Forschungszentrum

Research focus: MOLECULAR PATHOGENESIS OF LUNG AND PLEURAL DISEASES

PI: Luka Brcic

Focus: Pathogenetic mechanisms of progression, migration, and metastasis of lung and pleural tumors. Mechanisms by which the tumor microenvironment and the immune system are involved in the development and progression of lung and pleural diseases. Comparison/correlation of the development of desmoplastic stromal reaction in tumors with the development of fibrotic processes in fibrosing lung diseases.

Network: Within the Med Uni Graz we cooperate with the Clinical Department for Oncology and Pulmonology, University Clinic for Internal Medicine, Clinical Department for Thoracic Surgery and Hyperbaric Surgery, University Clinic for Surgery, and Chair for Pharmacology. There is a very close connection to the LBI for Pulmonary Vascular Research, Graz. Our national and international cooperation partners are: AKH Vienna, University Clinic for Surgery, Clinical Department for Thoracic Surgery, University Medicine Göttingen, Institute for Pathology, The University Clinic of Pulmonary and Allergic Diseases Golnik, Department of Pathology, Golnik, Slovenia, Institute for Pathology am University Hospital Essen, University of Duisburg Essen, Essen, Germany, MESOPATH College, MESONAT, MESOBANK, Department of BioPathology Center Léon Bérard, Lyon, France. Other partners in specific research projects are the Institute of Pathology, Klinik München-Bogenhausen, Germany, University of Groningen, Department of Pathology and Medical Biology, the Pathology Department of Yale School of Medicine, and Department of Pathology, Nagasaki University.

Projects

Pathogenesis of fibrosing pneumonia

  • Fibrosing pneumonia is classified into Usual Interstitial Pneumonia (UIP), Non-Specific Interstitial Pneumonia (NSIP), Organizing Pneumonia (OP), and unclassifiable Fibrosis. UIP is a deadly disease causing the death of patients within 3-4 years. Therapy can slow the process, but is not curative. The UIP pattern is either associated with chronic autoimmune disease, hypersensitivity, or comes as an idiopathic disorder. Several possible pathogenetic mechanisms have been identified, among them senescence and deregulation of the immune system. This is the focus of this project.
  • Duration: 2019-2021
  • Funded by: Medical University of Graz, D&R Institute of Pathology
  • Project partners: Institute of Pathology, Clinics München-Bogenhausen, München, Germany

MesoViBe- Mesothelioma Virtual Bank Austria

  • The idea of the project is to prospectively collect all newly diagnosed mesothelioma in Austria. The slides and blocks are sent to us, and we re-analyze them, perform additional immunohistochemistry, and FISH analysis for CDKN2A, and confirm the diagnosis. All slides are digitized and with minimal clinical data set stored on an online platform. The aim is to have all mesothelioma diagnosed in Austria in a virtual space by 2025.
  • Duration: 2020-2025
  • Funded by: AUVA, City of Graz, Takeda, BMS
  • Project partners: all pathological institutes in Austria that diagnose mesothelioma

Prognostic and predictive relevance of small cell lung carcinoma subtypes

  • Small cell lung carcinoma (SCLC) can be subtyped based on genes signaling for the neuroendocrine phenotype. Four different genes have been identified in cell cultures, ASCL1, and NeuroD, both neuroendocrine master regulators, POU2F3, a gene expressed in peripheral lung cells which inhibits a neuroendocrine phenotype, and YAP1. Immunohistochemical expression of those and some additional markers will be evaluated in the archival tissues. Same analyses will be performed on the cases of large cell neuroendocrine carcinoma
  • Duration: 2021-2022
  • Funded by: Medical University of Graz, D&R Institute of Pathology

The role of senescence, and the impact of neuronal receptors in Chronic Obstructive Lung Disease

  • This project analyses the role of senescence in maintaining chronic inflammation in Chronic Obstructive Lung Disease (COPD). Furthermore, the potential changes in neural structures their causes, and consequences are investigated.
  • Duration: 2021-2023
  • Funded by: Medical University of Graz, D&R Institute of Pathology
  • Project partners: Wim Timens, University of Groningen, University Medical Center, Dept. Pathology and Medical Biology

Diagnostic and Research Institute of Pathology

Ass.-Prof. Priv.-Doz. DDr.
Luka Brcic  
T: +43 316 385 71713