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Lipidhydrolyse
LipidhydrolyseMed Uni Graz

Publikationen

Publikationen, die in Zusammenarbeit mehrerer SFB Subprojekte entstanden sind, sind mit einem Stern gekennzeichnet. Namen von Principal Investigators und kooptierten Principal Investigators sind fett, Mitwirkende an den Plattformen sind fett kursiv gekennzeichnet.

Wissenschaftliche Veröffentlichungen

2025

  • *Bradic I, Kuentzel KB, Pirchheim A, Rainer S, Schwarz B, Trauner M, Larsen MR, Vujic N, Kratky D. From LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism. Biochim Biophys Acta Mol Cell Biol Lipids. 2025; 1870:159575. doi: 10.1016/j.bbalip.2024.159575.

2024

  • *Bulfon D, Breithofer J, Grabner GF, Fawzy N, Pirchheim A, Wolinski H, Kolb D, Hartig L, Tischitz M, Zitta C, Bramerdorfer G, Lass A, Taschler U, Kratky D, Greimel P, Zimmermann R. Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells. Nat Commun. 2024; 15:9937. doi: 10.1038/s41467-024-54213-1.

  • *Breithofer J, Bulfon D, Fawzy N, Tischitz M, Zitta C, Hartig L, Grabner GF, Pirchheim A, Hackl H, Taschler U, Lass A, Tam-Amersdorfer C, Strobl H, Kratky D, Zimmermann R. Phospholipase A2 group IVD mediates the transacylation of glycerophospholipids and acylglycerols. J Lipid Res. 2024; 65:100685. doi: 10.1016/j.jlr.2024.100685.

  • *Dixon ED, Claudel T, Nardo AD, Riva A, Fuchs C, Mlitz V, Busslinger G, Schnarnagl H, Stojakovic T, Senéca J, Hinteregger H, Grabner GF, Kratky D, Verkade H, Zimmermann R, Haemmerle G, Trauner M. Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice. J Hepatol. 2024 Sep 30:S0168-8278(24)02577-7. doi: 10.1016/j.jhep.2024.09.037.

  • Bandres-Meriz J, Sanz-Cuadrado MI, Hurtado de Mendoza I, Majali-Martinez A, Honeder SE, Cindrova-Davies T, Birner-Gruenberger R, Dalgaard LT, Desoye G. MCM proteins are up-regulated in placentas of women with reduced insulin sensitivity. Biosci Rep. 2024 Oct 30;44(10):BSR20240430. doi: 10.1042/BSR20240430.

  • Majerníková N., Marmolejo-Garza A., Salinas CS, Luu M. D. A., Zhang Y., Trombetta-Lima M., Tomin T., Birner-Gruenberger R., Lehtonen Š., Koistinaho J.,  Wolters J. C., Ayton S., den Dunnen W. F. A. & Dolga A. M. The link between amyloid β and ferroptosis pathway in Alzheimer’s disease progression. Cell Death & Disease volume 15, Article number: 782 (2024).

  • Buerger M, Amor M, Akhmetshina A, Bianco V, Perfler B, Zebisch A, Weichhart T, Kratky D. Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12. Int J Mol Sci. 2024; 25(20):11001. https://doi.org/10.3390/ijms25201100

  • Amor M, Diaz M, Bianco V, Svecla M, Schwarz B, Rainer S, Pirchheim A, Schooltink L, Mukherjee S, Grabner GF, Beretta G, Lamina C, Norata GD, Hackl H, Kratky D. Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model. Cardiovasc Diabetol. 2024; 23:298. doi: 10.1186/s12933-024-02397-7.

  • Handl V, Waldherr L, Arbring Sjöström T, Abrahamsson T, Seitanidou M, Erschen S, Gorischek A, Bernacka-Wojcik I, Saarela H, Tomin T, Honeder SE, Distl J, Huber W, Asslaber M, Birner-Grünberger R, Schäfer U, Berggren M, Schindl R, Patz S, Simon DT, Ghaffari-Tabrizi-Wizsy N. Continuous iontronic chemotherapy reduces brain tumor growth in embryonic avian in vivo models. J Control Release. 2024 May; 369:668-683. doi: 10.1016/j.jconrel.2024.03.044.

  • Kohlmayr JM, Grabner GF, Nusser A, Höll A, Manojlović V, Halwachs B, Masser S, Jany-Luig E, Engelke H, Zimmermann R, Stelzl U. Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis. Nat Commun. 2024 Mar 21;15(1):2516. doi: 10.1038/s41467-024-46937-x.
     
  • Bradić I, Vujić N, Kuentzel KB, Habisch H, Pirchheim A, Akhmetshina A, Henderson JD, Madl T, Deshmukh AS, Kratky D. Lanifibranor Reduces Inflammation and Improves Dyslipidemia in Lysosomal Acid Lipase-Deficient Mice. Gastro Hep Advances 2024, 3:711-723. doi: 10.1016/j.gastha.2024.05.006.
     
  • *Akhmetshina A, Bianco V, Bradic I, Korbelius M, Pirchheim A, Kuentzel KB, Eichmann TO, Hinteregger H, Kolb D, Habisch H, Liesinger L, Madl T, Sattler W, Radovic B, Sedej S, Birner-Gruenberger R, Vujic N, Kratky D. Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice. Mol Metab. 2024. 79:101869. doi: 10.1016/j.molmet.2023.101869.
     
  • Bianco V, Svecla M, Vingiani GB, Kolb D, Schwarz B, Buerger M, Beretta G, Norata GD, Kratky D. Regional Differences in the Small Intestinal Proteome of Control Mice and of Mice Lacking Lysosomal Acid Lipase..J Proteome Res 2024, 23:1506-18. doi: 10.1021/acs.jproteome.4c00082.
     
  • Reinisch I, Michenthaler H, Sulaj A, Moyschewitz E, Krstic J, Galhuber M, Xu R, Riahi Z, Wang T, Vujic N, Amor M, Zenezini Chiozzi R, Wabitsch M, Kolb D, Georgiadi A, Glawitsch L, Heitzer E, Schulz TJ, Schupp M, Sun W, Dong H, Ghosh A, Hoffmann A, Kratky D, Hinte LC, von Meyenn F, Heck AJR, Bluher M, Herzig S, Wolfrum C, Prokesch A. Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape. Nat Commun. 2024; 15:1391. 79:101869, doi: 10.1038/s41467-024-45724-y
     
  • Xu R, Vujic N, Bianco V, Reinisch I, Kratky D, Krstic J, Prokesch A. Lipid-associated macrophages between aggravation and alleviation of metabolic diseases. Trends Endocrinol Metab. 2024. doi: 10.1016/j.tem.2024.04.009.

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2023

  • Hofer P, Grabner GF, König M, Xie H, Bulfon D, Ludwig AE, Wolinski H, Zimmermann R, Zechner R, Heier C. Cooperative lipolytic control of neuronal triacylglycerol by spastic paraplegia-associated enzyme DDHD2 and ATGL. J Lipid Res. 2023 Nov; 64(11):100457. doi: 10.1016/j.jlr.2023.100457.
     
  • Macháček T, Fuchs CD, Winkelmann F, Frank M, Scharnagl H, Stojakovic T, Sombetzki M, Trauner M. Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity. Liver Int. 2023 Nov;43(11):2469-2478. doi: 10.1111/liv.15710.
     
  • Truong JK, Li J, Li Q, Pachura K, Rao A, Gumber S, Fuchs CD, Feranchak AP, Karpen SJ, Trauner M, Dawson PA. Active enterohepatic cycling is not required for the choleretic actions of 24-norUrsodeoxycholic acid in mice. JCI Insight. 2023 Mar 22;8(6):e149360. doi: 10.1172/jci.insight.149360.
     
  • Fuchs CD, Claudel T, Mlitz V, Riva A, Menz M, Brusilovskaya K, Haller F, Baumgartner M, Königshofer P, Unger LW, Sjöland W, Scharnagl H, Stojakovic T, Busslinger G, Reiberger T, Marschall HU, Trauner M. GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2-/- Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling. Cell Mol Gastroenterol Hepatol. 2023;16(5):847-856. doi: 10.1016/j.jcmgh.2023.08.003.
     
  • Grander C, Meyer M, Steinacher D, Claudel T, Hausmann B, Pjevac P, Grabherr F, Oberhuber G, Grander M, Brigo N, Jukic A, Schwärzler J, Weiss G, Adolph TE, Trauner M, Tilg H. 24-Norursodeoxycholic acid ameliorates experimental alcohol-related liver disease and activates hepatic PPARγ. JHEP Rep. 2023 Aug 3;5(11):100872. doi: 10.1016/j.jhepr.2023.100872.
     
  • Kulminskaya N, Rodriguez Gamez CF, Hofer P, Cerk IK, Dubey N, Viertlmayr R, Sagmeister T, Pavkov-Keller T, Zechner R, Oberer M. Unmasking Crucial Residues in Adipose Triglyceride Lipase (ATGL) for Co-Activation with Comparative Gene Identification-58 (CGI-58). J Lipid Res. 2023 Dec 20:100491. doi: 10.1016/j.jlr.2023.100491.
     
  • Colaço-Gaspar M, Hofer P, Oberer M, Zechner R. PNPLA-mediated lipid hydrolysis and transacylation - At the intersection of catabolism and anabolism. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Nov 9:159410. doi: 10.1016/j.bbalip.2023.159410 
     
  • Eliaš J, Fellner K, Hofer P, Oberer M, Schreiber R, Zechner R. The Potential Roles of Transacylation in Intracellular Lipolysis and Related Qssa Approximations. Bull Math Biol. 2023 Aug 6;85(9):82. doi: 10.1007/s11538-023-01188-7.
     
  • Sean A. Hardy, Laura Liesinger, Ralph Patrick, Maria Poettler, Lavinia Rech, Juergen Gindlhuber, Nishani S. Mabotuwana, DiyaaEldin Ashour, Verena Stangl, Mark Bigland, Lucy A. Murtha, Malcolm R. Starkey, Daniel Scherr, Philip M. Hansbro, Gerald Hoefler, Gustavo Campos Ramos, Clement Cochain, Richard P. Harvey, Ruth Birner-Gruenberger, Andrew J. Boyle, Peter P. Rainer. Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction. JACC: Basic to Translational Science, 8(12), 1539-1554, 2023. https://doi.org/10.1016/j.jacbts.2023.05.010.
     
  • Radkohl, A.; Schusterbauer, V.; Bernauer, L.; Rechberger, G.N.; Wolinski, H.; Schittmayer, M.; Birner-Gruenberger, R.; Thallinger, G.G.; Leitner, E.; Baeck, M.; et al. Human Sterols Are Overproduced, Stored and Excreted in Yeasts. Int. J. Mol. Sci. 2024, 25, 781. https://doi.org/10.3390/ijms25020781.
     
  • Schrom, S.; Kleinegger, F.; Anders, I.; Hebesberger, T.; Karner, C.; Liesinger, L.; Birner-Gruenberger, R.; Renner, W.; Pichler, M.; Grillari, R.; et al. MUG CCArly: A Novel Autologous 3D Cholangiocarcinoma Model Presents an Increased Angiogenic Potential. Cancers 2023, 15, 1757. https://doi.org/10.3390/cancers15061757
     
  • Murtha LA, Hardy SA, Mabotuwana NS, Bigland MJ, Bailey T, Raguram K, Liu S, Ngo DT, Sverdlov AL, Tomin T, Birner-Gruenberger R, Hume RD, Iismaa SE, Humphreys DT, Patrick R, Chong JJH, Lee RJ, Harvey RP, Graham RM, Rainer PP, Boyle AJ. Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction. Sci Rep 13, 14995 (2023). https://doi.org/10.1038/s41598-023-41894-9.

  • Bianco V, Kratky D. Glycoprotein Non-Metastatic Protein B (GPNMB): The Missing Link Between Lysosomes and Obesity. Exp Clin Endocrinol Diabetes. 2023; 131(12):639-645; doi: 10.1055/a-2192-0101

  • Amor M, Bianco V, Buerger M, Lechleitner M, Vujic N, Dobrijevic A, Akhmetshina A, Pirchheim A, Schwarz B, Pessentheiner AR, Baumgartner F, Rampitsch K, Schauer S, Klobucar I, Degoricija V, Pregartner G, Kummer D, Svecla M, Sommer G, Kolb D, Holzapfel GA, Hoefler G, Frank S, Norata GD, Kratky D. Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice. Cardiovasc Diabetol. 2023; 22(1):327 doi: 10.1186/s12933-023-02064-3

  • *Bradic I, Liesinger L, Kuentzel KB, Vujic N, Trauner M, Birner-Gruenberger R, Kratky D. Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase. J Lipid Res. 2023:100427. doi: 10.1016/j.jlr.2023.100427.

  • *Bianco V, Korbelius M, Vujic N, Akhmetshina A, Amor M, Kolb D, Pirchheim A, Bradic I, Kuentzel KB, Buerger M, Schauer S, Phan HTT, Bulfon D, Hoefler G, Zimmermann R, Kratky D. Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration. Mol Metab. 2023:101737. doi: 10.1016/j.molmet.2023.101737.

  • Kolleritsch S, Pajed L, Tilp A, Hois V, Potoschnig I, Kien B, Diwoky C, Hoefler G, Schoiswohl G, Haemmerle G. Adverse cardiac remodeling augments adipose tissue ß-adrenergic signaling and lipolysis counteracting diet-induced obesity. J Biol Chem. 2023 May 5:104788. doi: 10.1016/j.jbc.2023.104788. Online ahead of print. PMID: 37150323

  • Honeder SE, Tomin T, Schinagl M, Pfleger R, Hoehlschen J, Darnhofer B, Schittmayer M, Birner-Gruenberger R. Research Advances Through Activity-Based Lipid Hydrolase Profiling. Isr J Chem. 2023; 63(3-4): https://doi.org/10.1002/ijch.202200078

  • *Chalhoub G, Jamnik A, Pajed L, Kolleritsch S, Hois V, Bagaric A, Prem D, Tilp A, Kolb D, Wolinski H, Taschler U, Züllig T, Rechberger GN, Fuchs C, Trauner M, Schoiswohl G, Haemmerle G. Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism. Mol Metab. 2023 Jun;72:101725. doi: 10.1016/j.molmet.2023.101725.

  • *Berger N, van der Wel T, Hirschmugl B, Baernthaler T, Gindlhuber J, Fawzy N, Eichmann TO, Birner-Gruenberger R, Zimmermann R, van der Stelt M, Wadsack C. Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta. Front Endocrinol (Lausanne). 2023 Feb 14;14:1092024. doi: 10.3389/fendo.2023.1092024. eCollection 2023.

  • Hoehlschen J, Hofreither D, Tomin T, Birner-Gruenberger R. Redox-driven cardioprotective effects of sodium-glucose co-transporter-2 inhibitors: comparative review, Cardiovasc Diabetol. 2023 Apr 29;22(1):101. doi: 10.1186/s12933-023-01822-7. Review.

  • Akhmetshina A, Kratky D, Rendina-Ruedy E. Influence of Cholesterol on the Regulation of Osteoblast Function. Metabolites. 2023; 13(4):578. https://doi.org/10.3390/metabo13040578

  • Goeritzer M, Kuentzel KB, Beck S, Korbelius M, Rainer S, Bradić I, Kolb D, Mussbacher M, Schrottmaier WC, Assinger A, Schlagenhauf A, Rost R, Gottschalk B, Eichmann TO, Züllig T, Graier WF, Vujić N, Kratky D. Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice. Intl J Mol Sci. 2023; 24(4):3116. doi.org/10.3390/ijms24043116.

  • Liebscher G, Vujic N, Schreiber R, Heine M, Krebiehl C, Duta-Mare M, Lamberti G, de Smet CH, Hess MW, Eichmann TO, Holzl S, Scheja L, Heeren J, Kratky D, Huber LA. The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue. Mol Metab. 2023:101705. doi: 10.1016/j.molmet.2023.101705.

  • Korbelius M, Kuentzel KB, Bradić I, Vujić N, Kratky D. Recent Insights into Lysosomal Acid Lipase Deficiency. Trends Mol Med. 2023. doi: 10.1016/j.molmed.2023.03.001.

2022

  • Trauner M, Fuchs CD. Novel therapeutic targets for cholestatic and fatty liver disease. Gut. 2022 Jan;71(1):194-209. doi: 10.1136/gutjnl-2021-324305.

  • Fuchs CD, Trauner M. Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology. Nat Rev Gastroenterol Hepatol. 2022 Jul;19(7):432-450. doi: 10.1038/s41575-021-00566-7.

  • *Eisner H, Riegler-Berket L, Gamez CFR, Sagmeister T, Chalhoub G, Darnhofer B, Jazleena PJ, Birner-Gruenberger R, Pavkov-Keller T, Haemmerle G, Schoiswohl G, Oberer M. The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1. Int J Mol Sci. 2022 Oct 28;23(21):13101. doi: 10.3390/ijms232113101.

  • Kien B, Kolleritsch S, Kunowska N, Heier C, Chalhoub G, Tilp A, Wolinski H, Stelzl U, Haemmerle G. Lipid droplet-mitochondria coupling via perilipin 5 augments respiratory capacity but is dispensable for FA oxidation. J Lipid Res. 2022 Mar;63(3):100172. doi: 10.1016/j.jlr.2022.100172. Epub 2022 Jan 21. PMID: 35065923 Free PMC article.

  • *Grabner GF, Guttenberger N, Mayer N, Migglautsch-Sulzer AK, Lembacher-Fadum C, Fawzy N, Bulfon D, Hofer P, Zullig T, Hartig L, Kulminskaya N, Chalhoub G, Schratter M, Radner FPW, Preiss-Landl K, Masser S, Lass A, Zechner R, Gruber K, Oberer M, Breinbauer R, Zimmermann R. Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes. J Am Chem Soc. 2022, 144:6237-50. doi: 10.1021/jacs.1c10836.

  • Xie H, Heier C, Meng X, Bakiri L, Pototschnig I, Tang Z, Schauer S, Baumgartner VJ, Grabner GF, Schabbauer G, Wolinski H, Robertson GR, Hoefler G, Zeng W, Wagner EF, Schweiger M, Zechner R. An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. Proc Natl Acad Sci USA. 2022; 119(9):e2112840119. doi: 10.1073/pnas.2112840119.

  • Kuentzel KB, Bradić I, Mihalič ZN, Korbelius M, Rainer S, Pirchheim A, Kargl J, Kratky D. Dysregulation of Placental Lipid Hydrolysis by High-Fat/High-Cholesterol Feeding and Gestational Diabetes Mellitus in Mice. International Journal of Molecular Sciences. 2022; 23(20):12286. doi.org/10.3390/ijms232012286

  • *Patel R, Santoro A, Hofer P, Tan D, Oberer M, Nelson A T, Konduri S, Siegel D, Zechner R, Saghatelian A, Kahn, BB. ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature. 2022, 606(7916):968-975.doi: 10.1038/s41586-022-04787-X.

  • Fuchs CD, Dixon ED, Hendrikx T, Mlitz V, Wahlström A, Ståhlman M, Scharnagl H, Stojakovic T, Binder CJ, Marschall HU, Trauner M.Tetrahydroxylated bile acids improve cholestatic liver and bile duct injury in the Mdr2-/- mouse model of sclerosing cholangitis via immunomodulatory effects. Hepatol Commun. 2022 Sep;6(9):2368-2378. doi: 10.1002/hep4.1998. Epub 2022 Jun 12.

  • *Pusch LM, Riegler-Berket L, Oberer M, Zimmermann R, Taschler U. α/β-Hydrolase Domain-Containing 6 (ABHD6)- A Multifunctional Lipid Hydrolase. Metabolites. 2022 Aug 18;12(8):761. doi: 10.3390/metabo12080761.

  • Gindlhuber J, Schinagl M, Liesinger L, Darnhofer B, Tomin T, Schittmayer M, Birner-Gruenberger R. Hepatocyte Proteome Alterations Induced by Individual and Combinations of Common Free Fatty Acids. Int J Mol Sci. 2022 Mar 20;23(6):3356. doi: 10.3390/ijms23063356. PMID: 35328776 Free PMC article.

  • *Bradic I, Kuentzel KB, Honeder S, Grabner GF, Vujic N, Zimmermann R, Birner-Gruenberger R, Kratky D. Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases. Mol Metab. 2022:101510. doi: 10.1016/j.molmet.2022.101510.

  • Joshi L, Plastira I, Bernhart E, Reicher H, Koshenov Z, Graier WF, Vujic N, Kratky D, Rivera R, Chun J, Sattler W. Lysophosphatidic Acid Receptor 5 (LPA5) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro. Cells. 2022; 11(7):1071. doi.org/10.3390/cells11071071

  • Goeritzer M, Schlager S, Kuentzel KB, Vujić N, Korbelius M, Rainer S, Kolb D, Mussbacher M, Salzmann M, Schrottmaier WC, Assinger A, Schlagenhauf A, Madreiter-Sokolowski CT, Blass S, Eichmann TO, Graier WF, Kratky D. Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo. Cells. 2022; 11(5):850. doi.org/10.3390/cells11050850

  • *Korbelius, M; Vujić, N; Kuentzel, KB;  Obrowsky, S; Rainer, S; Haemmerle, G; Rülicke, T; Kratky, D. Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis. Biochim Biophys Acta Mol Cell Biol Lipids. 2022; 1867(4), 15912 doi: 10.1016/j.bbalip.2022.159121

  • *Fuchs CD, Radun R, Dixon ED, Mlitz V, Timelthaler G, Halilbasic E, Herac M, Jonker JW, Ronda OAHO, Tardelli M, Haemmerle G, Zimmermann R, Scharnagl H, Stojakovic T, Verkade HJ, Trauner M. Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. Hepatology. 2022 Jan;75(1):125-139. doi: 10.1002/hep.32112. Epub 2021 Dec 4.PMID: 34387896

  • *Riegler-Berket L, Wechselberger L, Cerk IK, Padmanabha Das KM, Viertlmayr R, Kulminskaya N, Rodriguez Gamez CF, Schweiger M, Zechner R, Zimmermann R., Oberer M. Residues of the minimal sequence of G0S2 collectively contribute to ATGL inhibition while C-and N-terminal extensions promote binding to ATGL. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jan 10;1867(3):159105. doi: 10.1016/j.bbalip.2021.159105. Online ahead of print. PMID: 35026402

  • Zhou Q, Kerbl-Knapp J, Zhang F, Korbelius M, Kuentzel KB, Vujić N, Akhmetshina A, Hörl G, Paar M, Steyrer E, Kratky D, Madl T. Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism. Metabolites. 2022; 12(1):17. doi.org/10.3390/metabo12010017

2021

  • Atallah R, Gindlhuber J, Platzer W, Bärnthaler T, Tatzl E, Toller W, Strutz J, Rittchen S, Luschnig P, Birner-Gruenberger R, Wadsack C, Heinemann A. SUCNR1 Is Expressed in Human Placenta and Mediates Angiogenesis: Significance in Gestational Diabetes. Int J Mol Sci. 2021 Nov 7;22(21):12048. doi: 10.3390/ijms222112048. PMID: 34769478 Free PMC article.

  • Leblanc FJA, Hassani FV, Liesinger L, Qi X, Naud P, Birner-Gruenberger R, Lettre G, Nattel S.  Transcriptomic Profiling of Canine Atrial Fibrillation Models After One Week of Sustained Arrhythmia. Circ Arrhythm Electrophysiol. 2021 Aug;14(8):e009887. doi: 10.1161/CIRCEP.121.009887. Epub 2021 Jul 16. PMID: 34270327 Free PMC article.

  • Darnhofer B, Tomin T, Liesinger L, Schittmayer M, Tomazic PV, Birner-Gruenberger R. Comparative proteomics of common allergenic tree pollens of birch, alder, and hazel. Allergy. 2021 Jun;76(6):1743-1753. doi: 10.1111/all.14694. Epub 2021 Jan 15. PMID: 33301602 Free PMC article.

  • Grabner GF, Xie H, Schweiger M, Zechner R. Lipolysis: cellular mechanisms for lipid mobilization from fat stores. Nat Metab. 2021 Nov;3(11):1445-1465. doi: 10.1038/s42255-021-00493-6. Epub 2021 Nov 19. PMID: 34799702 Review.

  • *Schinagl M, Tomin T, Gindlhuber J, Honeder S, Pfleger R, Schittmayer M, Trauner M, Birner-Gruenberger R. Proteomic Changes of Activated Hepatic Stellate Cells. Int J Mol Sci. 2021 Nov 26;22(23):12782. doi: 10.3390/ijms222312782. PMID: 34884585 Free PMC article.
  • Trauner M, Fuchs CD. Novel therapeutic targets for cholestatic and fatty liver disease. Gut. 2022 Jan;71(1):194-209. doi: 10.1136/gutjnl-2021-324305. Epub 2021 Oct 6. PMID: 34615727 Free PMC article. Review.
  • Sachdev V, Duta-Mare M, Korbelius M, Vujic N, Leopold C, Freark de Boer J, Rainer S, Fickert P, Kolb D, Kuipers F, Radovic B, Gorkiewicz G and Kratky D. Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase.  Cells 2021, 10(10), 2619; doi.org/10.3390/cells10102619.
  • Kuentzel KB, Bradić I, Akhmetshina A, Korbelius M, Rainer S, Kolb D, Gauster M, Vujić N, Kratky D. Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth. Int J Mol Sci. 2021 Sep 27;22(19):10416. doi: 10.3390/ijms221910416.
  • Grininger C, Leypold M, Aschauer P, Pavkov-Keller T, Riegler-Berket L, Breinbauer R, Oberer M. Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket. Biomolecules. 2021 Sep 1;11(9):1299. doi: 10.3390/biom11091299.
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  • Tardelli M, Bruschi FV, Fuchs CD, Claudel T, Auer N, Kunczer V, Ronda OAHO, Verkade HJ, Stojakovic T, Scharnagl H, Trauner M. Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice. Int J Mol Sci. 2021 Feb 20;22(4):2126. doi: 10.3390/ijms22042126.
  • Dixon ED, Nardo AD, Claudel T, Trauner M. The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD. Genes (Basel). 2021 Apr 26;12(5):645. doi: 10.3390/genes12050645. Review.
  • Nardo AD, Schneeweiss-Gleixner M, Bakail M, Dixon ED, Lax SF, Trauner M. Pathophysiological mechanisms of liver injury in COVID-19. Liver Int. 2021 Jan;41(1):20-32. doi: 10.1111/liv.14730. Epub 2020 Nov 29. Review.
  • Zhu C, Boucheron N, Müller AC, Májek P, Claudel T, Halilbasic E, Baazim H, Lercher A, Viczenczova C, Hainberger D, Preglej T, Sandner L, Alteneder M, Gülich AF, Khan M, Hamminger P, Remetic J, Ohradanova-Repic A, Schatzlmaier P, Donner C, Fuchs CD, Stojakovic T, Scharnagl H, Sakaguchi S, Weichhart T, Bergthaler A, Stockinger H, Ellmeier W, Trauner M. 24-NorUrsodeoxycholic acid reshapes immunometabolism in CD8+ T-cells and alleviates hepatic inflammation. J Hepatol. 2021 Jul 6:S0168-8278(21)01886-9. doi: 10.1016/j.jhep.2021.06.036. Online ahead of print.
  • Zhang F, Kerbl-Knapp J, Colman M J R, Pertschy B, Kratky D, Madl T. Global analysis of protein arginine methylation. Cell Reports Methods. 2021 Jun; 1, 100016. doi.org/10.1016/j.crmeth.2021.100016
  • Reich M, Spomer L, Klindt C, Fuchs K, Stindt J, Deutschmann K, Höhne J, Liaskou E, Hov JR, Karlsen TH, Beuers U, Verheij J, Ferreira-Gonzalez S, Hirschfield G, Forbes SJ, Schramm C, Esposito I, Nierhoff D, Fickert P, Fuchs CD, Trauner M, García-Beccaria M, Gabernet G, Nahnsen S, Mallm JP, Vogel M, Schoonjans K, Lautwein T, Köhrer K, Häussinger D, Luedde T, Heikenwalder M, Keitel V. Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis. J Hepatol. 2021 Sep;75(3):634-646. doi: 10.1016/j.jhep.2021.03.029. Epub 2021 Apr 17.
  • *Pajed L, Taschler U, Tilp A, Hofer P, Kotzbeck P, Kolleritsch S, Radner FPW, Pototschnig I, Wagner C, Schratter M, Eder S, Huetter S, Schreiber R, Haemmerle G, Eichmann TO, Schweiger M, Hoefler G, Kershaw EE, Lass A, Schoiswohl G. Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase. Commun Biol. 2021 Mar 10;4(1):323. doi: 10.1038/s42003-021-01858-z.
  • *Chalhoub G, Kolleritsch S, Maresch LK, Taschler U, Pajed L, Tilp A, Eisner H, Rosina P, Kien B, Radner FPW, Schicho R, Oberer M, Schoiswohl G, Haemmerle G. Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease. J Lipid Res. 2021 Apr 17;62:100075. doi: 10.1016/j.jlr.2021.100075.
  • *Fuchs CD, Radun R, Dixon ED, Mlitz V, Timelthaler G, Halilbasic E, Herac M, Jonker JW, Ronda OAHO, Tardelli M, Haemmerle G, Zimmermann R, Scharnagl H, Stojakovic T, Verkade HJ, Trauner M. Hepatocyte-specific deletion of adipose triglyceride lipase (ATGL/PNPLA2) ameliorates dietary induced steatohepatitis in mice. Hepatology. 2021 Aug 13. doi: 10.1002/hep.32112. Online ahead of print.
  • Honeder S, Tomin T, Nebel L, Gindlhuber J, Fritz-Wallace K, Schinagl M, Heininger C, Schittmayer M, Ghaffari-Tabrizi-Wizsy N, Birner-Gruenberger R. Adipose Triglyceride Lipase Loss Promotes a Metabolic Switch in A549 Non-Small Cell Lung Cancer Cell Spheroids. Mol Cell Proteomics. 2021 May 14;20:100095. doi: 10.1016/j.mcpro.2021.100095. Online ahead of print.
  • Tomin T, Schittmayer M, Sedej S, Bugger H, Gollmer J, Honeder S, Darnhofer B, Liesinger L, Zuckermann A, Rainer PP, Birner-Gruenberger R. Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts. Int J Mol Sci. 2021 Feb 11;22(4):1787. doi: 10.3390/ijms22041787.
  • Tomin T, Bordag N, Zügner E, Al-Baghdadi A, Schinagl M, Birner-Gruenberger R, Schittmayer M. Blood Plasma Quality Control by Plasma Glutathione Status. Antioxidants (Basel). 2021 May 27;10(6):864. doi: 10.3390/antiox10060864.
  • Sveidahl Johansen O, Ma T, Hansen JB, Markussen LK, Schreiber R, Reverte-Salisa L, Dong H, Christensen DP, Sun W, Gnad T, Karavaeva I, Nielsen TS, Kooijman S, Cero C, Dmytriyeva O, Shen Y, Razzoli M, O'Brien SL, Kuipers EN, Nielsen CH, Orchard W, Willemsen N, Jespersen NZ, Lundh M, Sustarsic EG, Hallgren CM, Frost M, McGonigle S, Isidor MS, Broholm C, Pedersen O, Hansen JB, Grarup N, Hansen T, Kjær A, Granneman JG, Babu MM, Calebiro D, Nielsen S, Rydén M, Soccio R, Rensen PCN, Treebak JT, Schwartz TW, Emanuelli B, Bartolomucci A, Pfeifer A, Zechner R, Scheele C, Mandrup S, Gerhart-Hines Z. Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. Cell. 2021 Jun 24;184(13):3502-3518.e33. doi: 10.1016/j.cell.2021.04.037. Epub 2021 May 27.
  • Waldherr L, Seitanidou M, Jakešová M, Handl V, Honeder S, Nowakowska M, Tomin T, Karami Rad M, Schmidt T, Distl J, Birner-Gruenberger R, von Campe G, Schäfer U, Berggren M, Rinner B, Asslaber M, Ghaffari-Tabrizi-Wizsy N, Patz S, Simon DT, Schindl R. Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump. Adv Mater Technol. 2021 May;6(5):2001302. doi: 10.1002/admt.202001302. Epub 2021 Apr 12.
  • Zhang F, Kerbl-Knapp J, Akhmetshina A, Korbelius M, Kuentzel KB, Vujić N, Hörl G, Paar M, Kratky D, Steyrer E, Madl T. Tissue-Specific Landscape of Metabolic Dysregulation during Ageing. Biomolecules. 2021 Feb 7;11(2):235. doi: 10.3390/biom11020235. PMID: 33562384
  • Vujić N, Bradić I, Goeritzer M, Kuentzel KB, Rainer S, Kratky D, Radović B. ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages. Autophagy. 2021 Jan 18:1-6. doi: 10.1080/15548627.2021.1874132.
  • Brejchova K, Radner FPW, Balas L, Paluchova V, Cajka T, Chodounska H, Kudova E, Schratter M, Schreiber R, Durand T, Zechner R, Kuda O. Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides. Proc Natl Acad Sci U S A. 2021 Jan;118(2):e2020999118. doi: 10.1073/pnas.2020999118.
  • Helderman RC, Whitney DG, Duta-Mare M, Akhmetshina A, Vujic N, Jayapalan S, Nyman JS, Misra BB, Rosen CJ, Czech MP, Kratky D, Rendina-Ruedy E. Loss of Function of Lysosomal Acid Lipase (LAL) Profoundly Impacts Osteoblastogenesis and Increases Fracture Risk in Humans. Bone. 2021:115946. doi: 10.1016/j.bone.2021.115946.
  • Schilcher I, Stadler JT, Lechleitner M, Hrzenjak A, Berghold A, Pregartner G, Lhomme M, Holzer M, Korbelius M, Reichmann F, Springer A, Wadsack C, Madl T, Kratky D, Kontush A, Marsche G, Frank S. Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL. Int. J. Mol. Sci. 2021, 22, 719. doi.org/10.3390/ijms22020719
  • Galhuber M, Kupper N, Dohr G, Gauster M, Kwapiszewska G, Olschewski A, Jandl K, Gschwandtner E, Schweiger M, Kratky D, Leitinger G, Prokesch A, Kolb D. Histochem Cell Biol. Simple method of thawing cryo-stored samples preserves ultrastructural features in electron microscopy. 2021 Jan 6. doi: 10.1007/s00418-020-01952-z. Online ahead of print. PMID: 33404705

2020

  • *Kintscher U, Foryst-Ludwig A, Haemmerle G, Zechner R. The Role of Adipose Triglyceride Lipase and Cytosolic Lipolysis in Cardiac Function and Heart Failure. Cell Rep Med. 2020 Mar 25;1(1):100001. doi: 10.1016/j.xcrm.2020.100001. eCollection 2020 Apr 21. Review.
  • Bruschi FV, Tardelli M, Einwallner E, Claudel T, Trauner M. PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells. Int J Mol Sci. 2020 Nov 18;21(22):8711. doi: 10.3390/ijms21228711.
  • Wunderling K, Leopold C, Jamitzky I, Yaghmour M, Zink F, Kratky D, Thiele C. Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir. Mol Metab. 2020:101150. doi: 10.1016/j.molmet.2020.101150.
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  • Vujic N, Korbelius M, Sachdev V, Rainer S, Zimmer A, Huber A, Radovic B, Kratky D. Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden. Atherosclerosis. 2020 Aug 10; 310:26-36. doi: 10.1016/j.atherosclerosis.2020.07.030.
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  • *Tardelli M, Bruschi FV, Claudel T, Fuchs CD, Auer N, Kunczer V, Stojakovic T, Scharnagl H, Habib A, Grabner GF, Zimmermann R, Lotersztajn S, Trauner M. Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption. J Lipid Res. 2019 Jul;60(7):1284-1292. doi: 10.1194/jlr.M093369. Epub 2019 May 2. PMID: 31048404 Free PMC article.
  • Olivieri O, Speziali G, Castagna A, Pattini P, Udali S, Pizzolo F, Liesinger L, Gindlhuber J, Tomin T, Schittmayer M, Birner-Gruenberger R, Cecconi D, Girelli D, Friso S, Martinelli N. The Positive Association between Plasma Myristic Acid and ApoCIII Concentrations in Cardiovascular Disease Patients Is Supported by the Effects of Myristic Acid in HepG2 Cells. J Nutr. 2020 Jul:nxaa202. doi: 10.1093/jn/nxaa202. Online ahead of print. PMID: 32710763
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  • Fuchs CD, Krivanec S, Steinacher D, Mlitz V, Wahlström A, Stahlman M, Claudel T, Scharnagl H, Stojakovic T, Marschall HU, Trauner M. Absence of Bsep/Abcb11 attenuates MCD-diet induced hepatic steatosis but aggravates inflammation in mice. Liver Int. 2020 Jun;40(6):1366-1377. doi: 10.1111/liv.14423. Epub 2020 Mar 18. PubMed PMID: 32141703.
  • *Hofer P, Taschler U, Schreiber R, Kotzbeck P, Schoiswohl G. The Lipolysome-A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation.  Metabolites. 2020 Apr 10;10(4):147. doi: 10.3390/metabo10040147. PMID: 32290093 Free PMC article. Review.
  • Radulović S, Gottschalk B, Hörl G, Zardoya-Laguardia P, Schilcher I, Hallström S, Vujić N, Schmidt K, Trieb M, Graier WF, Malli R, Kratky D, Marsche G, Frank S. Endothelial lipase increases eNOS activating capacity of high-density lipoprotein. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158612. doi: 10.1016/j.bbalip.2020.158612. Epub 2020 Jan 7. PubMed PMID: 31923467.
  • Bruschi FV, Tardelli M, Herac M, Claudel T, Trauner M. Metabolic regulation of hepatic PNPLA3 expression and severity of liver fibrosis in patients with NASH. Liver Int. 2020 Feb 11. doi: 10.1111/liv.14402. [Epub ahead of print] PubMed PMID: 32043752.
  • Tomin T, Schittmayer M, Birner-Gruenberger R. Addressing Glutathione Redox Status in Clinical Samples by Two-Step Alkylation with N-ethylmaleimide Isotopologues. Metabolites. 2020 Feb;10(2):71. doi: 10.3390/metabo10020071. PMID: 32079090 Free PMC article.
  • Wallner M, Eaton DM, Berretta RM, Liesinger L, Schittmayer M, Gindlhuber J, Wu J, Jeong MY, Lin YH, Borghetti G, Baker ST, Zhao H, Pfleger J, Blass S, Rainer PP, von Lewinski D, Bugger H, Mohsin S, Graier WF, Zirlik A, McKinsey TA, Birner-Gruenberger R, Wolfson MR, Houser SR. HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction. Sci Transl Med. 2020 Jan;12(525):eaay7205. doi: 10.1126/scitranslmed.aay7205. PMID: 31915304 Free PMC article.

2019

  • *Tardelli M, Bruschi FV, Fuchs CD, Claudel T, Auer N, Kunczer V, Baumgartner M, A H O Ronda O, Verkade HJ, Stojakovic T, Scharnagl H, Habib A, Zimmermann R, Lotersztajn S, Trauner M. Monoacylglycerol Lipase Inhibition Protects From Liver Injury in Mouse Models of Sclerosing Cholangitis. Hepatology. 2019. doi: 10.1002/hep.30929. [Epub ahead of print] PubMed PMID: 31505038.
  • *Jebessa ZH, Shanmukha Kumar D, Dewenter M, Lehmann LH, Xu C, Schreiter F, Siede D, Gong XM, Worst BC, Federico G, Sauer SW, Fischer T, Wechselberger L, Müller OJ, Sossalla S, Dieterich C, Most P, Gröne HJ, Moro C, Oberer M, Haemmerle G, Katus HA, Tyedmers J, Backs J. The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. Nat Metab. 2019;1(11):1157-1167. doi: 10.1038/s42255-019-0138-4. PubMed PMID: 31742248; PubMed Central PMCID: PMC6861130.
  • Korbelius M, Vujic N, Sachdev V, Obrowsky S, Rainer S, Gottschalk B, Graier WF, Kratky D. ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes. Cell Rep. 2019;28(7):1923-1934.e4. doi:10.1016/j.celrep.2019.07.030. PubMed PMID: 31412256.
  • Bruschi FV, Claudel T, Tardelli M, Starlinger P, Marra F, Trauner M. PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells. Hepatol Commun. 2019 Jul 15;3(9):1191-1204. doi: 10.1002/hep4.1395. eCollection 2019 Sep. PubMed PMID: 31497741; PubMed Central PMCID: PMC6719741.
  • *Tardelli M, Bruschi FV, Claudel T, Fuchs CD, Auer N, Kunczer V, Stojakovic T, Scharnagl H, Habib A, Grabner GF, Zimmermann R, Lotersztajn S, Trauner M. Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption. J Lipid Res. 2019. 60(7):1284-1292. doi: 10.1194/jlr.M093369. Epub 2019 May 2. PubMed PMID:31048404; PubMed Central PMCID: PMC6602129.
  • Kulminskaya N, Oberer M. Protein-protein interactions regulate the activity of Adipose Triglyceride Lipase in intracellular lipolysis. Biochimie. 2019; pii: S0300-9084(19)30236-6. doi: 10.1016/j.biochi.2019.08.004. [Epub ahead of print] PubMed PMID: 31404588.
  • Tomin T, Schittmayer M, Honeder S, Heininger C, Birner-Gruenberger R. Irreversible oxidative post-translational modifications in heart disease. Expert Rev Proteomics. 2019:1-13. doi: 10.1080/14789450.2019.1645602. [Epub ahead of print] PubMed PMID: 31361162.