2024
Bradic I, Kuentzel KB, Pirchheim A, Rainer S, Schwarz B, Trauner M, Larsen MR, Vujic N, Kratky D. From LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism. Biochim Biophys Acta Mol Cell Biol Lipids. 2025; 1870(1):159575 doi: 10.1016/j.bbalip.2024.159575 Majerníková N, Marmolejo-Garza A, Salinas CS, Luu MDA, Zhang Y, Trombetta-Lima M, Tomin T, Birner-Gruenberger R, Lehtonen Š, Koistinaho J, Wolters JC, Ayton S, den Dunnen WFA, Dolga AM. The link between amyloid β and ferroptosis pathway in Alzheimer's disease progression. Cell Death Dis. 2024; 15(10):782 doi: 10.1038/s41419-024-07152-0 Buerger M, Amor M, Akhmetshina A, Bianco V, Perfler B, Zebisch A, Weichhart T, Kratky D. Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12. Int J Mol Sci. 2024; 25(20):11001 doi: 10.3390/ijms252011001 Pilic J, Oflaz FE, Gottschalk B, Erdogan YC, Graier WF, Malli R. Visualizing VDAC1 in live cells using a tetracysteine tag. PLoS One. 2024; 19(10):e0311107 doi: 10.1371/journal.pone.0311107 Bandres-Meriz J, Sanz-Cuadrado MI, Hurtado de Mendoza I, Majali-Martinez A, Honeder SE, Cindrova-Davies T, Birner-Gruenberger R, Dalgaard LT, Desoye G. MCM Proteins are Upregulated in Placentas of Women with Reduced Insulin Sensitivity. Biosci Rep. 2024; 44(10):BSR20240430 doi: 10.1042/BSR20240430 Madreiter-Sokolowski CT, Hiden U, Krstic J, Panzitt K, Wagner M, Enzinger C, Khalil M, Abdellatif M, Malle E, Madl T, Osto E, Schosserer M, Binder CJ, Olschewski A. Targeting organ-specific mitochondrial dysfunction to improve biological aging. Pharmacol Ther. 2024; 21:108710 doi: 10.1016/j.pharmthera.2024.108710 Erdogan YC, Pilic J, Gottschalk B, Yigit EN, Zaki AG, Öztürk G, Eroglu E, Okutan B, Sommer NG, Weinberg AM, Schindl R, Graier WF, Malli R. Development of a Dual Reporter System to Simultaneously Visualize Ca2+ Signals and AMPK Activity. ACS Sens. 2024; 9(9):4680-9 doi: 10.1021/acssensors.4c01058 Amor M, Diaz M, Bianco V, Svecla M, Schwarz B, Rainer S, Pirchheim A, Schooltink L, Mukherjee S, Grabner GF, Beretta G, Lamina C, Norata GD, Hackl H, Kratky D. Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model. Cardiovasc Diabetol. 2024; 23(1):298. doi: 10.1186/s12933-024-02397-7 Hofer SJ, Daskalaki I, Bergmann M, Frišcic J, Zimmermann A, Mueller MI, Abdellatif M, Nicastro R, Masser S, Durand S, Nartey A, Waltenstorfer M, Enzenhofer S, Faimann I, Gschiel V, Bajaj T, Niemeyer C, Gkikas I, Pein L, Cerrato G, Pan H, Liang Y, Tadic J, Jerkovic A, Aprahamian F, Robbins CE, Nirmalathasan N, Habisch H, Annerer E, Dethloff F, Stumpe M, Grundler F, Wilhelmi de Toledo F, Heinz DE, Koppold DA, Rajput Khokhar A, Michalsen A, Tripolt NJ, Sourij H, Pieber TR, de Cabo R, McCormick MA, Magnes C, Kepp O, Dengjel J, Sigrist SJ, Gassen NC, Sedej S, Madl T, De Virgilio C, Stelzl U, Hoffmann MH, Eisenberg T, Tavernarakis N, Kroemer G, Madeo F. Spermidine is essential for fasting-mediated autophagy and longevity. Nat Cell Biol. 2024; 26(9):1571-84 doi: 10.1038/s41556-024-01468-x Bradic I, Vujic N, Kuentzel KB, Habisch H, Pirchheim A, Akhmetshina A, Henderson JD, Madl T, Deshmukh AS, Kratky D. Lanifibranor Reduces Inflammation and Improves Dyslipidemia in Lysosomal Acid Lipase-Deficient Mice. Gastro Hep Advances 2024; 3:711-23. doi: 10.1016/j.gastha.2024.05.006 Neuß T, Chen MC, Wirges N, Usluer S, Oellinger R, Lier S, Dudek M, Madl T, Jastroch M, Steiger K, Schmitz W, Einwächter H, Schmid RM. Metabolic Reprogramming Is an Initial Step in Pancreatic Carcinogenesis That Can Be Targeted to Inhibit Acinar-to-Ductal Metaplasia. Cancer Res. 2024; 84(14):2297-312. doi: 10.1158/0008-5472.CAN-23-2213 Pilic J, Gottschalk B, Bourgeois B, Habisch H, Koshenov Z, Oflaz FE, Erdogan YC, Miri SM, Yigit EN, Aydin MS, Öztürk G, Eroglu E, Shoshan-Barmatz V, Madl T, Graier WF, Malli R. Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress. Mol Cell. 2024; 84:2732-46 doi: 10.1016/j.molcel.2024.06.009 Gottschalk B, Koshenov Z, Malli R, Graier WF. Implications of mitochondrial membrane potential gradients on signaling and ATP production analyzed by correlative multi-parameter microscopy. Sci Rep. 2024; 14(1):14784 doi: 10.1038/s41598-024-65595-z Clarke A, Skerjanz J, Gsell MAF, Wiedner P, Erkan-Candag H, Groschner K, Stockner T, Tiapko O. PIP2 modulates TRPC3 activity via TRP helix and S4-S5 linker. Nat Commun. 2024; 15(1):5220 doi: 10.1038/s41467-024-49396-6 Babalola JA, Stracke A, Loeffler T, Schilcher I, Spyridon S, Flunkert S, Neddens J, Lignell A, Prokesch M, Panzenboeck U, Strobl H, Tadic J, Leitinger G, Lass A, Hutter-Paier B, Hoefler G. Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice. Mol Metab. 2024; 85:101959 doi: 10.1016/j.molmet.2024.101959 Corrigendum in Mol Metab. 2024; 23:101972 doi: 10.1016/j.molmet.2024.101972 Xu R, Vujic N, Bianco V, Reinisch I, Kratky D, Krstic J, Prokesch A. Lipid-associated macrophages between aggravation and alleviation of metabolic diseases. Trends Endocrinol Metab. 2024; 35(11):981-95 doi: 10.1016/j.tem.2024.04.009 Kaptein P, Slingerland N, Metoikidou C, Prinz F, Brokamp S, Machuca-Ostos M, de Roo G, Schumacher TNM, Yeung YA, Moynihan KD, Djuretic IM, Thommen DS. CD8-targeted IL2 unleashes tumor-specific immunity in human cancer tissue by reviving the dysfunctional T cell pool. Cancer Discov. 2024; 14(7):1226-51 doi: 10.1158/2159-8290.CD-23-1263 Huber K, Giralt A, Dreos R, Michenthaler H, Geller S, Barquissau V, Ziegler DV, Tavernari D, Gallart-Ayala H, Krajina K, Jonas K, Ciriello G, Ivanisevic J, Prokesch A, Pichler M, Fajas L. E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells. Biochim Biophys Acta Mol Cell Res. 2024; 1871(5):119721. doi: 10.1016/j.bbamcr.2024.119721 Bianco V, Svecla M, Vingiani GB, Kolb D, Schwarz B, Buerger M, Beretta G, Norata GD, Kratky D. Regional Differences in the Small Intestinal Proteome of Control Mice and of Mice Lacking Lysosomal Acid Lipase. J. Proteome Res. 2024; 23(4):1506-18. doi: 10.1021/acs.jproteome.4c00082 Schulze A, Zimmermann A, Kainz K, Egger NB, Bauer MA, Madeo F, Carmona-Gutierrez D. Assessing chronological aging in Saccharomyces cerevisiae. Methods Cell Biol. 2024; 181:87-108. doi: 10.1016/bs.mcb.2022.09.006 Akhmetshina A, Bianco V, Bradić I, Korbelius M, Pirchheim A, Kuentzel KB, Eichmann TO, Hinteregger H, Kolb D, Habisch H, Liesinger L, Madl T, Sattler W, Radović B, Sedej S, Birner-Gruenberger R, Vujić N, Kratky D. Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice. Mol Metab. 2024; 79:101869 doi: 10.1016/j.molmet.2023.101869 Usluer S, Galhuber M, Khanna Y, Bourgeois B, Spreitzer E, Michenthaler H, Prokesch A, Madl T. Disordered regions mediate the interaction of p53 and MRE11. Biochim Biophys Acta Mol Cell Res. 2024; 1871(2):119654 doi: 10.1016/j.bbamcr.2023.119654 Jonas K, Prinz F, Ferracin M, Krajina K, Deutsch A, Madl T, Rinner B, Slaby O, Klec C, Pichler M. MiR-4646-5p Acts as a Tumor-Suppressive Factor in Triple Negative Breast Cancer and Targets the Cholesterol Transport Protein GRAMD1B. Non-Coding RNA. 2024; 10(1):2 doi: 10.3390/ncrna10010002 Liu L, Zhou S, Zaufel A, Xie Z, Racedo S, Wagner M, Zollner G, Fickert P, Zhang Q. Bile acids regulate SF-1 to alter cholesterol balance in adrenocortical cells via S1PR2. Biochem Biophys Res Commun. 2024; 692:149342 doi: 10.1016/j.bbrc.2023.149342
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