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Bluemel G, Planque M, Madreiter-Sokolowski CT, Haitzmann T, Hrzenjak A, Graier WF,Fendt S-M, Olschewski H, Leithner K. PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells. Free Radic Biol Med. 2021; 176:34-45. doi: 10.1016/j.freeradbiomed.2021.09.007 Tiffner A, Hopl V, Schober R, Sallinger M, Grabmayr H, Höglinger C, Fahrner M, Lunz V, Maltan L, Frischauf I, Krivic D, Bhardwaj R, Schindl R, Hediger MA, Derler I. Orai1 Boosts SK3 Channel Activation. Cancers (Basel). 2021; 13(24):6357 doi: 10.3390/cancers13246357 Koyani CN, Scheruebel S, Jin G, Kolesnik E, Zorn-Pauly K, Mächler H, Hoefler G, von Lewinski D, Heinzel FR, Pelzmann B, Malle E. Hypochlorite-Modified LDL Induces Arrhythmia and Contractile Dysfunction in Cardiomyocytes. Antioxidants (Basel). 2021; 11(1):25 doi: 10.3390/antiox11010025 Neuendorf CS, Vignolle GA, Derntl C, Tomin T, Novak K, Mach RL, Birner-Gruenberger R, Pfluegl S. A quantitative metabolic analysis reveals Acetobacterium woodii as a flexible and robust host for formate-based bioproduction. Metab Eng. 2021; 68:68-85doi: 10.1016/j.ymben.2021.09.004 Habisch H, Zhang F, Zhou Q, Madl T. Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy. J Vis Exp. 2021; 178 doi: 10.3791/63245 Bauer MA, Kainz K, Ruckenstuhl C, Madeo F, Carmona-Gutierrez D. Murals meet microbes: at the crossroads of microbiology and cultural heritage. Microb Cell. 2021; 8(12):276-9 doi: 10.15698/mic2021.12.765 Schinagl M, Tomin T, Gindlhuber J, Honeder S, Pfleger R, Schittmayer M, Trauner M, Birner-Gruenberger R. Proteomic Changes of Activated Hepatic Stellate Cells. Int J Mol Sci. 2021; 22(23):12782 doi: 10.3390/ijms222312782 Vujić N, Bradić I, Goeritzer M, Kuentzel KB, Rainer S, Kratky D, Radović B. ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages. Autophagy. 2021; 17(11):3402-7 doi: 10.1080/15548627.2021.1874132 Atallah R, Gindlhuber J, Platzer W, Bärnthaler T, Tatzl E, Toller W, Strutz J, Rittchen S, Luschnig P, Birner-Gruenberger R, Wadsack C, Heinemann A. SUCNR1 Is Expressed in Human Placenta and Mediates Angiogenesis: Significance in Gestational Diabetes. Int J Mol Sci. 2021; 22(21):12048 doi: 10.3390/ijms222112048 Wahida A, Müller M, Hiergeist A, Popper B, Steiger K, Branca C, Tschurtschenthaler M, Engleitner T, Donakonda S, De Coninck J, Öllinger R, Pfautsch MK, Müller N, Silva M, Usluer S, Oberg ET, Böttcher JP, Pfarr N, Anton M, Slotta-Huspenina JB, Nerlich AG, Madl T, Basic M, Bleich A, Berx G, Ruland J, Knolle PA, Rad R, Adolph TE, Vandenabeele P, Kanegane H, Gessner A, Jost PJ, Yabal M. XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells. Sci Immunol. 2021; 6(65):eabf7235 doi: 10.1126/sciimmunol.abf7235 Usluer S, Spreitzer E, Bourgeois B, Madl T. p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR. Int J Mol Sci. 2021; 22(21):11431 doi: 10.3390/ijms222111431 Lenard AJ, Hutten S, Zhou Q, Usluer S, Zhang F, Bourgeois BMR, Dormann D, Madl T. Phosphorylation regulates CIRBP arginine methylation, transportin-1 binding and liquid-liquid phase separation. Front Mol Biosci. 2021; 8:689687 doi: 10.3389/fmolb.2021.689687 Sachdev V, Duta-Mare M, Korbelius M, Vujic N, Leopold C, de Boer JF, Rainer S, Fickert P, Kolb D, Kuipers F, Radovic B, Gorkiewicz G, Kratky D. Impaired bile acid metabolism and gut dysbiosis in mice lacking lysosomal acid lipase. Cells. 2021; 10(10):2619 doi: 10.3390/cells10102619 Kuentzel KB, Bradic I, Akhmetshina A, Korbelius M, Rainer S, Kolb D, Gauster M, Vujic N, Kratky D. Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth. Int J Mol Sci. 2021; 22(19):10416 doi: 10.3390/ijms221910416 Hofer SJ, Davinelli S, Bergmann M, Scapagnini G, Madeo F. Caloric Restriction Mimetics in Nutrition and Clinical Trials. Front Nutr. 2021; 8:717343 doi: 10.3389/fnut.2021.717343 Posch F, Prinz F, Balihodzic A, Mayr C, Kiesslich T, Klec C, Jonas K, Barth DA, Riedl JM, Gerger A, Pichler M. MiR-200c-3p Modulates Cisplatin Resistance in Biliary Tract Cancer by ZEB1-Independent Mechanisms. Cancers. 2021; 13(16):3996 doi: 10.3390/cancers13163996 Oflaz FE, Koshenov Z, Hirtl M, Rost R, Bachkoenig OA, Gottschalk B, Madreiter-Sokolowski CT, Malli R, Graier WF. Near-UV Light Induced ROS Production Initiates Spatial Ca2+ Spiking to Fire NFATc3 Translocation. Int J Mol Sci. 2021; 22(15):8189 doi: 10.3390/ijms22158189 Koshenov Z, Oflaz FE, Hirtl M, Pilic J, Bachkoenig OA, Gottschalk B, Madreiter-Sokolowski CT, Rost R, Malli R, Graier WF. Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress. Metabolites. 2021; 11(7):422 doi: 10.3390/metabo11070422 Zhang F, Kerbl-Knapp J, Rodriguez Colman MJ, Meinitzer A, Macher T, Vujic N, Fasching S, Jany-Luig E, Korbelius M, Kuentzel KB, Mack M, Akhmetshina A, Pirchheim A, Paar M, Rinner B, Hörl G, Steyrer E, Stelzl U, Burgering B, Eisenberg T, Pertschy B, Kratky D, Madl T. Global analysis of protein arginine methylation. Cell Reports Methods. 2021; 1(2):100016 doi: 10.1016/j.crmeth.2021.100016 Somlapura M, Gottschalk B, Lahiri P, Kufferath I, Pabst D, Rülicke T, Graier WF, Denk H, Zatloukal K. Different Roles of p62 (SQSTM1) Isoforms in Keratin-Related Protein Aggregation. Int J Mol Sci. 2021; 22(12):6227 doi: 10.3390/ijms22126227 Tomin T*, Bordag N*, Zuegner E, Al-Badgdadi A, Schinagl M, Birner-Gruenberger R, Schittmayer M. Blood Plasma Quality Control by Plasma Glutathione Status. Antioxidants. 2021; 10(6):864 (*equal contribution) doi: 10.3390/antiox10060864 Honeder S, Tomin T, Nebel L, Gindlhuber J, Fritz-Wallace K, Schinagl M, Heininger C, Schittmayer M, Ghaffari-Tabrizi-Wizsy N, Birner-Gruenberger R. Adipose Triglyceride Lipase Loss Promotes a Metabolic Switch in A549 Non-Small Cell Lung Cancer Cell Spheroids. Mol Cell Proteomics. 2021; 20:100095 doi: 10.1016/j.mcpro.2021.100095 Zhou Q, Usluer S, Zhang F, Lenard AJ, Bourgeois BMR, Madl T. ATP regulates RNA-driven cold inducible RNA binding protein phase separation. Protein Sci. 2021; 30(7):1438-53 doi: 10.1002/pro.4123 Zaufel A, van de Wiel SMW, Yin L, Fauler G, Chien D, Dong X, Gilmer JF, Truong JK, Dawson P, van de Graaf SFJ, Fickert P, Moustafa T. Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions. Biochim Biophys Acta Mol Basis Dis. 2021; 1867(8):166153 doi: 10.1016/j.bbadis.2021.166153 Chalhoub G, Kolleritsch S, Maresch LK, Taschler U, Pajed L, Tilp A, Natmessnig H, Rosina P, Kien B, Radner FPW, Schicho R, Oberer M, Schoiswohl G, Haemmerle G. Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease. J Lipid Res. 2021; 62:100075 doi: 10.1016/j.jlr.2021.100075 Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F. Dietary spermidine improves cognitive function. Cell Rep. 2021; 35(2):108985 doi: 10.1016/j.celrep.2021.108985 Waldherr L, Seitanidou M, Jakešová M, Handl V, Honeder S, Nowakowska M, Tomin T, Karami Rad M, Schmidt T, Distl J, Birner-Gruenberger R, von Campe G, Schäfer U, Berggren M, Rinner B, Asslaber M, Ghaffari-Tabrizi-Wizsy N, Patz S, Simon DT, Schindl R. Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump. Adv Mater Technol. 2021; 6(5):2001302 doi: 10.1002/admt.202001302 Helderman RC, Whitney DG, Duta-Mare M, Akhmetshina A, Vujic N, Jayapalan S, Nyman JS, Misra BB, Rosen CJ, Czech MP, Kratky D, Rendina-Ruedy E. Loss of Function of Lysosomal Acid Lipase (LAL) Profoundly Impacts Osteoblastogenesis and Increases Fracture Risk in Humans. Bone. 2021; 148:115946 doi: 10.1016/j.bone.2021.115946 Bischof H, Burgstaller S, Springer A, Matt L, Rauter T, Bachkönig OA, Schmidt T, Groschner K, Schindl R, Madl T, Plesnila N, Lukowski R, Graier WF, Malli R. Potassium ions promote hexokinase-II dependent glycolysis. iScience. 2021; 24(4):102346 doi: 10.1016/j.isci.2021.102346 Balihodzic A, Barth DA, Prinz F, Pichler M. Involvement of Long Non-Coding RNAs in Glucose Metabolism in Cancer. Cancers (Basel). 2021; 13(5):977 doi: 10.3390/cancers13050977 Joshi L, Plastira I, Bernhart E, Reicher H, Koyani CN, Madl T, Madreiter-Sokolowski C, Koshenov Z, Graier WF, Hallström S, Sattler W. Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia. Int J Mol Sci. 2021; 22(4):1968 doi: 10.3390/ijms22041968 Zhang F, Kerbl-Knapp J, Akhmetshina A, Korbelius M, Kuentzel KB, Vujic N, Hörl G, Paar M, Kratky D, Steyrer E, Madl T. Tissue-Specific Landscape of Metabolic Dysregulation during Ageing. Biomolecules. 2021; 11(2):235 doi: 10.3390/biom11020235 Tomin T, Schittmayer M, Sedej S, Bugger H, Gollmer J, Honeder S, Darnhofer B, Liesinger L, Zuckermann A, Rainer PP, Birner-Gruenberger R. Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts. Int J Mol Sci. 2021; 22:1787 doi: 10.3390/ijms22041787 Madreiter-Sokolowski CT, Gottschalk B, Sokolowski AA, Malli R, Graier WF. Dynamic Control of Mitochondrial Ca2+ Levels as a Survival Strategy of Cancer Cells. Front Cell Dev Biol. 2021; 9:614668 doi: 10.3389/fcell.2021.614668 Schilcher I, Stadler JT, Lechleitner M, Hrzenjak A, Berghold A, Pregartner G, Lhomme M, Holzer, M, Korbelius M, Reichmann F, Springer A, Wadsack C, Madl T, Kratky D, Kontush A, Marsche G, Frank S. Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL. Int J Mol Sci. 2021; 22(2):719 doi: 10.3390/ijms22020719 Wunderling K, Leopold C, Jamitzky I, Yaghmour M, Zink F, Kratky D, Thiele C. Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir. Mol Metab. 2021; 45:101150 doi: 10.1016/j.molmet.2020.101150 Parrado-Fernandez C, Leoni V, Saeed A, Rodriguez-Rodriguez P, Sandebring-Matton A, Beldad-Cordoba C, Bueno P, Gali CC, Panzenboeck U, Cedazo-Minguez A, Björkhem I. Sex-difference in flux of 27-hydroxycholesterol in the brain. Br J Pharmacol. 2021; 178(16):3194-204 doi: 10.1111/bph.15353 Richter G, Gui T, Bourgeois B, Koyani CN, Ulz P, Heitzer E, von Lewinski D, Burgering BMT, Malle E, Madl T. β-catenin regulates FOXP2 transcriptional activity via multiple binding sites. FEBS J. 2021; 288(10):3261-84 doi: 10.1111/febs.15656 Darnhofer B*, Tomin T*, Liesinger L, Schittmayer M, Tomazic P, Birner-Gruenberger R. Comparative proteomics of common allergenic tree pollens of birch, alder and hazel. Allergy. 2021; 76(6):1743-53 doi: 10.1111/all.14694 (*equal contribution) Cavinato M, Madreiter-Sokolowski CT, Büttner S, Schosserer M, Zwerschke W, Wedel S, Grillari J, Graier WF, Jansen-Dürr P. Targeting cellular senescence based on inter-organelle communication, multi-level proteostasis and metabolic control. FEBS J. 2021; 288(12):3834-54 doi: 10.1111/febs.15631
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