Ernst Malle
Projects within the DK-MCD
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Yeast: a cellular model for hypochlorous acid- induced cell death co-supervised together with Frank Madeo |
Ali Alavian Ghavanini graduated |
Signaling cascade in cardiomyocytes in response to HOCl-LDL |
Chintan Koyani graduated |
Research interest
Myeloperoxidase (MPO) is a heme protein released into the extracellular space and phagocytic vacuoles by activated phagocytes. HOCl, a potent two-electron oxidant formed by the MPO-H2O2-halide-system in vitro and in vivo, plays an important role in the immune system. Excessive HOCl generation, however, results in tissue damage. MPO and HOCl are emerging as critical modulators of vascular injury by promoting inflammatory arterial pathology and formation of mature plaques. HOCl reacts with a wide range of biological substrates, including antioxidants, amines, sulfides, nucleotides, DNA, lipids, and lipoproteins, compounds that in turn adversely affect biological activities of various target cells.
Curriculum vitae
| 1973 - 1981 | Study of Chemistry/Physics/Pharmacy at the University of Graz | |
| 1981- 1984 | PhD Thesis in Medical Biochemistry at the Institute of Medical Biochemistry, University of Graz | |
| 1985 - 1990 | PostDoc/Assistant Professor at the Institute of Physiology, Institute of Pediatrics and Institute of Medical Biochemistry, University of Graz | |
| 1990 - 1992 | PostDoctoral Training at the Department of Internal Medicine, Division of Endocrinology and Metabolism, Phillips University, Marburg/Lahn, Germany | |
| 1992 - 1995 | Assistant Professor at the Institute of Medical Biochemistry, University of Graz | |
| 1995 - 2003 | Associate Professor at the Institute of Medical Biochemistry and Medical Molecular Biology, University of Graz | |
| 2004 - | Associate Professor at the Institute of Molecular Biology and Biochemistry, Medical University of Graz | |