13th Scientific Retreat
25th - 27th September 2023
Seggau Castle
Monday, 25th of September14:25 Opening & Welcome Notes by the Speaker 14:30 - 16:00 Session 1
chaired by: Manu Kanti14:30 - 14:50 Sophie Honeder: Activity-based proteomic profiling reveals reduction of lipid hydrolase activity levels in lung tumors 14:50 – 15:10 Sarah Masser: Characterizing human PRMT – kinase interactions with a specific focus on PRMT5 15:10 – 15:30 Katharina Jonas: MiR-4646-5p acts as a tumor-suppressive factor in triple negative breast cancer by targeting the cholesterol transport protein GRAMD1B 15:30 – 15:50 Furkan E. Oflaz: Annexin-A5 is fundamental for VDAC1-dependent mitochondrial Ca2+ homeostasis and determines the susceptibility to apoptosis 15:50 – 16:10 Paola Peña de la Sancha: Adipose triglyceride lipase derived fatty acids control sterol regulatory element-binding protein-1c driven hepatic lipogenesis 16:10 - 16:40 Break 16:40 - 18:00 Session 2
chaired by: Felix Prinz16:40 - 17:00 Joshua A. Babalola: Neuroprotective effects of Astaxanthin in preclinical models of Alzheimer’s disease 17:00 - 17:20 Alina Jamnik: Ces2a deficiency provokes hepatic steatosis in mice 17:20 - 17:40 Sinem Usluer: Disordered regions mediate the interaction of p53 and MRE11 17:40 - 18:00 Anna Tilp: Chylomicron treatment of endothelial cells causes the release of small extracellular vesicles that stimulate lipid accumulation and pro-inflammatory pathways in underlying cells 18:00 - 19:00 Dinner 19:00 - 21:00 Poster & Wine Sophie Honeder
Sarah Masser
Katharina Jonas
Furkan E. Oflaz
Paola Peña de la Sancha
Joshua A. BabalolaAlina Jamnik
Sinem Usluer
Anna Tilp
Michelle Reynders
Martin Bürger![]()
![]()
![]()
![]()
![]()
![]()
Tuesday, 26th of September09:30 - 10:30 Faculty Meeting 10:30 - 11:50 Session 3
chaired by: Paola Peña de la Sancha10:30 - 10:50 Michelle Reynders: Liver-adipose tissue communication through mTORC1 10:50 - 11:10 Martin Bürger: Elucidating the consequences of MMP-12 loss in lysosomal acid lipase deficiency 11:10 - 11:30 Manu M. Kanti: Adipose triglyceride lipase (ATGL) mediated lipid metabolism fuels lung regeneration 11:30 - 11:50 Vanessa Jäger: Oncogene or tumor-suppressor? - Functional characterization of the plasma membrane rupture mediator Ninjurin 1 in lung cancer 12:00 - 13:00 Lunch 13:00 - 14:40 Session 4
chaired by: Katharina Jonas13:00 - 13:20 Alena Akhmetshina: Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles 13:20 - 13:40 Martin Hirtl: Super-resolution microscopy unveils intricate differences in sub-organelle distribution dynamics of MCU between excitable and non-excitable cells 13:40 - 14:00 Aneta Lenard: Optofluidic force induction enables quantitative analysis of size distribution and kinetics of biomolecular condensates 14:00 - 14:20 Felix Prinz: MicroRNA mimics can distort physiological microRNA effects on immune checkpoints by triggering an antiviral interferon response 15:00 Bus transfer - Styrian Fruit and Wine Trail Silberberg 17:30 Joint dinner at "Landgasthof Wratschko" ![]()
![]()
![]()
![]()
![]()
![]()
Wednesday, 27th of September09:00 - 10:40 Session 5
chaired by: Joshua A. Babalola09:00 - 09:20 Selena Trattner: Dietary protection against cognitive decline in Alzheimer’s disease mouse model by targeting polyamine pathway 09:20 - 09:40 Qishun Zhou: Tyrosine-mediated nuclear import of CIRBP reveals an alternative NLS recognition mechanism by TNPO3 09:40 - 10:00 Valentina Bianco: Regional differences in the small intestine proteome of control mice and of mice lacking lysosomal acid lipase 10:00 - 10:20 Olaf Bachkönig: Risperidones effect on the H1 receptor reveals a nonlinear relationship between cytosolic Ca2+ and mitochondrial Ca2+ uptake 10:20 - 10:40 Martina Bergmann: A novel platform for testing synergistic effects of anti-aging drugs 10:40 - 12:00 Poster & Coffee Felix Prinz
Alena Akhmetshina
Martin Hirtl
Aneta Lenard
Manu M. KantiSelena Trattner
Qishun Zhou
Valentina Bianco
Olaf Bachkönig
Martina Bergmann12:00 - 12:30 Concluding Remarks 12:30 Lunch ![]()
![]()
![]()
![]()
![]()
![]()