11th Scientific Retreat
27th - 29th September 2021
Seggau Castle
14:00 - 14:15 Opening & Welcome Notes by the Speaker & Students' Speakers 14:15 - 15:30 Session 1
chaired by: Sophie Honeder14:15 - 14:30 Aneta Lenard: Exploring the structural effects of arginine-to-citrulline conversion within the RG/RGG protein regions 14:30 - 14:45 Furkan E. Oflaz: The contribution of annexin V to mitochondrial Ca2+ uptake 14:45 - 15:00 Maximilian Schinagl: Obstructing lipolysis in liver cells decreases activation of neighbouring hepatic stellate cells 15:00 - 15:15 Felix Prinz: Double-stranded RNA triggers cancer cells’ innate immune responses and leads to the upregulation of immunosuppressive immune checkpoint molecules 15:15 - 15:30 Martin Buerger: Elucidating the consequences of MMP12 loss in lysosomal acid lipase deficiency 15:30 - 16:00 Break 16:00 - 18:00 Session 2
chaired by: Felix Prinz16:00 - 17:00 Keynote lecture:
Matthew vander Heiden, MD PhD: Understanding how metabolism supports cancer cell proliferation
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA17:00 - 17:15 Magdalena Lang: Factors determining human dendritic cell differentiation during inflammation 17:15 - 17:30 Sarah Masser: Dynamics of subcellular partitioning through protein modification 17:30 - 17:45 Manu M. Kanti: Role of adipose triglyceride lipase (ATGL) mediated substrate hydrolysis for alveolar type-2 pneumocyte function 17:45 - 18:00 Zhanat Koshenov: Presenilin-1 controls glycolysis via Ca2+ sensitive mitochondrial NADH shuttles 18:00 - 19:00 Dinner 19:00 - 20:15 Session 3
chaired by:19:00 - 19:15 Hermann Habacher: Establishing the Wnt-p53 interaction as a novel drug target 19:15 - 19:30 Anna Tilp: The role of human adipose triglyceride lipase in cardiac lipid signaling and energy metabolism 19:30 - 19:45 Maximilian Mack: Deciphering the function of Rps2 methylation by Hmt1 19:45 - 20:00 Ivan Bradić: Impact of lysosomal acid lipase inhibitors on neutral lipase activities 20:00 - 20:15 Vanessa Jaeger: Molecular mechanisms of transformation in lung cancer 20:15 - 21:15 1st Poster Session Aneta Lenard
Furkan E. Oflaz
Maximilian Schinagl
Felix Prinz
Martin Buerger
Magdalena Lang
Sarah MasserManu M. Kanti
Zhanat Koshenov
Hermann Habacher
Anna Tilp
Maximilian Mack
Ivan Bradić
Juergen Gindlhuber
09:00 - 10:30 Session 4
chaired by: Ivan Bradić09:00 - 09:15 Hazel Erkan: Optical lipid clamp analysis and md simulations suggest lipid binding domain 2 (L2) as the primary site for TRPC3 regulation by diacylglycerols 09:15 - 09:30 Valentina Bianco: Consequences of intestinal LAL deficiency on whole body lipid metabolism 09:30 - 09:45 Paola Peña de la Sancha: Regulation of sterol regulatory element binding protein (SREBP)-1c by adipose triglyceride lipase (ATGL) 09:45 - 10:00 Sinem Usluer: p53 transactivation domain mediates binding and phase separation with poly-PR/GR 10:00 - 10:30 Gabriel Chalhoub & Alina Jamnik: The role of carboxylesterase 2 proteins in hepatic and intestinal lipid metabolism 10:30 - 11:00 Break 11:00 - 12:25 Session 5
chaired by: Vanessa Jaeger11:00 - 11:15 Martina Bergmann: A novel platform for testing synergistic effects of anti-aging drugs 11:15 - 11:30 Martin Hirtl: JTV-519 inhibits MICU1-dependent mitochondrial Ca2+ uptake 11:30 - 11:45 Juergen Gindlhuber: Hepatic response to fatty acid treatment: A study of lipotoxicity, rescue and trans fatty acids 11:45 - 12:25 Alumni lecture:
Sumitra Mohan, PhD: Liquid biopsy analysis and personalised medicine
Cancer Research UK Manchester Institute, University of Manchester, UK12:25 - 13:25 Lunch 13:25 - 14:25 Faculty Meeting
"Kongress-Saal"Meeting of the Students' Faculty
"Spielsaal"14:30 - 17:30 Castle tour and wine tasting 18:00 - 19:00 Dinner 19:00 - 20:00 2nd Poster Session Hazel Erkan
Valentina Bianco
Paola Peña de la Sancha
Sinem Usluer
Gabriel Chalhoub & Alina Jamnik
Martina Bergmann
Martin HirtlQishun Zhou
Denis Krivić
Joshua A. Babalola
Katharina Jonas
Alena Akhmetshina
Olaf Bachkoenig
Sophie Honeder
09:00 - 10:15 Session 6
chaired by: Magdalena Lang09:00 - 09:15 Qishun Zhou: ATP regulates RNA-driven cold inducible RNA binding protein phase separation 09:15 - 09:30 Denis Krivić: Molding the immunological signature of mast cells by TRPC photopharmacology 09:30 - 09:45 Joshua A. Babalola: Neuroprotective effects of astaxanthin in preclinical models of Alzheimer’s disease 09:45 - 10:00 Katharina Jonas: MicroRNA miR-4646-5p is a novel tumor suppressive factor in triple negative breast cancer 10:00 - 10:15 Alena Akhmetshina: Consequences of lysosomal acid lipase deficiency on skeletal muscle formation and metabolism 10:15 - 10:45 Break 10:45 - 12:15 Session 7
chaired by:10:45 - 11:00 Olaf Bachkoenig: The inhibitory effect of risperidone on the Ca2+ homeostasis of the cellConsequences of lysosomal acid lipase deficiency on skeletal muscle formation and metabolism 11:00 - 11:15 Sophie Honeder: Lipid hydrolysis in lung cancer metabolism 11:15 - 12:15 Keynote lecture:
Dr. Christine Ziegler: Structure-function studies on transporters in membrane bilayers: An integral approach
Biophysics II / Department of Structural Biology, University of Regensburg, Germany12:15 - 12:30 Concluding Remarks 12:30 - 13:15 Lunch 
