10th Scientific Retreat
28th - 29th September 2020
MED CAMPUS Graz
08:45 Opening & Welcome Notes by the Speaker & Students' Speaker 09:00 - 10:30 Session 1
chaired by: Martina Bergmann & Selena Ristić09:00 - 09:15 Juergen Gindlhuber: Fatty acid species-dependent hepatic cellular lipotoxicity 09:15 - 09:30 Michelle Reynders: Gut/liver – adipose tissue communication through mTORC1 09:30 - 09:45 Olaf Bachkoenig: A short peptide sequence of UCP2s IML2 mediates mitochondrial Ca2+ uptake in epithelial cancer cell lines 09:45 - 10:00 Hermann Habacher: Establishing the Wnt-p53 interaction as a novel drug target 10:00 - 10:15 Benedikt Kien: Exploring the metabolic consequences of Perilipin 5-mediated lipid droplet-mitochondria coupling 10:15 - 10:30 Valentina Bianco: Consequences of intestinal LAL deficiency on whole body lipid metabolism 10:30 - 11:00 Break 11:00 - 12:30 Session 2
chaired by: Paola Peña de la Sancha & Manu Kanti11:00 - 11:15 Magdalena Lang: Nuclear receptor signaling in immune-metabolic functions of cerebrovascular endothelial cells in condition of Alzheimer’s disease 11:15 - 11:30 Katharina Jonas: Characterization of novel non-coding RNAs potentially involved in breast carcinogenesis and tumor cell metabolism 11:30 - 12:30 Keynote lecture:
Philipp J. Jost: Understanding tumor cell integrity to target cancer
Department for Hematology and Oncology & German Consortium for Translational Cancer Research (DKTK), University Hospital rechts der Isar, Technical University of Munich, Germany; Division of Oncology, Department of Internal Medicine, Medical University of Graz, Austria12:30 - 13:30 Lunch 13:30 - 15:00 Session 3
chaired by: Alena Akhmetshina & Ivan Bradić13:30 - 13:45 Martin Hirtl: Investigating spatial heterogeneity of mitochondrial Ca2+ uptake to ensure proper cardiomyocyte function 13:45 - 14:00 Aneta Lenard: Regulation of nuclear import and phase separation 14:00 - 14:15 Hazel Erkan: Exploring lipid sensitivity of TRPC channels 14:15 - 14:30 Sophie Honeder: Lipid hydrolysis in lung cancer metabolism 14:30 - 14:45 Qishun Zhou: Structural basis of nuclear localization signal recognition by TNPO3 14:45 - 15:00 Felix Prinz: Artificial miRNA mimics can distort physiological miRNA effects on immune checkpoint molecule expression by triggering an unspecific interferon response 15:00 - 15:30 Break 15:30 - 16:30 Faculty Meeting 16:00 - 18:00 Resilience Workshop for Students (online)
Adrian Marriott
Zurich, Switzerland
08:45 - 10:15 Session 4
chaired by: Gabriel Chalhoub & Benedikt Kien08:45 - 09:00 Selena Ristić: A screen for plant-derived compounds against Parkinson’s disease 09:00 - 09:15 Manu Manjunath Kanti: Adipose triglyceride lipase is needed for normal bronchiolar club cell metabolism 09:15 - 10:15 Alumni lecture:
Corina Madreiter-Sokolowski: Mitochondria as key regulators in aging
Department of Health Sciences and Technology, Institute of Translational Medicine, ETH Zurich, Switzerland; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University of Graz, Austria10:15 - 10:45 Break 10:45 - 12:00 Session 5
chaired by: Olaf Bachkoenig & Martin Hirtl10:45 - 11:00 Martin Vargek: Effect of FGF15 and FGF21 in gut-liver homeostasis 11:00 - 11:15 Alena Akhmetshina: Role of lysosomal acid lipase deficiency in skeletal muscle formation, development, and metabolism 11:15 - 11:30 Denis Krivić: TRPC channels as a target for optical control of immune responses 11:30 - 11:45 Maximilian Schinagl: Lipid storage and mobilization in liver disease 11:45 - 12:00 Anna Tilp: The role of human adipose triglyceride lipase in cardiac lipid signaling and energy metabolism 12:00 - 13:00 Lunch 13:00 - 14:30 Session 6
chaired by: Katharina Jonas & Felix Prinz13:00 - 13:15 Zhanat Koshenov: Citrin-mediated metabolic reprogramming in response to Ca2+ imbalance at mitochondrial surface 13:15 - 13:30 Ivan Bradić: Crosstalk of lysosomal lipid degradation in liver and adipose tissue 13:30 - 14:30 Keynote lecture:
Andreas Holzinger: Why explainable AI is important for medicine
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria; Visiting Professor for explainable AI at the xAI Lab of the Alberta Machine Intelligence Institute, University of Alberta, Edmonton, Canada15:00 - 16:30 Session 7
chaired by: Sophie Honeder & Qishun Zhou15:00 - 15:15 Martina Bergmann: A novel platform for testing synergistic effects of anti-aging drugs 15:15 - 15:30 Gabriel Chalhoub: The role of carboxylesterase 2 members in hepatic and intestinal lipid metabolism 15:30 - 15:45 Sarah Masser: Dynamics of subcellular partitioning through protein modification 15:45 - 16:00 Paola Peña de la Sancha: Regulation of sterol regulatory element binding protein (SREBP)-1 by monoglyceride lipase (MGL) 16:00 - 16:15 Joshua Adekunle Babalola: Protective effect of astaxanthin in Alzheimer’s disease by modulating insulin sensitivity and amyloid beta clearance via LRP1 activity in blood-brain barrier endothelial cells 16:15 - 16:30 Maximilian Mack: Hmt1 modulates Rps2-Tsr4 interaction via arginine methylation 16:30 - 17:00 Break 17:00 - 18:30 Session 8
chaired by: Michelle Reynders & Martin Vargek17:00 - 17:15 Furkan Enes Oflaz: The contribution of annexin V to mitochondrial Ca2+ uptake 17:15 - 17:30 Sinem Usluer: Deciphering the intricate code of RG/RGG regions in nuclear import and liquid-liquid phase separation 17:30 - 18:30 Alumni lecture:
Jianfeng Huang: Tumor macro-environment: Crosstalk between tumor and metabolic organs
Salk Institute for Biological Studies, La Jolla, USA18:30 Concluding Remarks 
