DK-MCD Retreat 2015

28^th - 30^th October 2015
Seggau Castle

Wednesday, 28^th of October

14:00 - 14:30 Opening & Welcome Notes by the Speaker and Students' speakers

Self-presentation of the new DK-MCD students:

H. Furkan Alkan

Madalina-Cristina Duta-Mare

Dina Hofer

Lisa Maresch

Zahra Safari

Wenmin Xia

14:30 - 16:30 Session 1
chaired by: Christina Leopold & Helmut Pelzmann

14:30 - 15:30 KeyNote Lecture:
Ira Goldberg: Glucose and white blood cells, unhappy together
Division of Endocrinology, Diabetes and Metabolism, NYU Langone Medical Center, New York, USA

15:30 - 15:45 Stephanie Kolleritsch: The role of Perilipin 5 in cardiomyocyte energy catabolism

15:45 - 16:00 H. Furkan Alkan: Investigating the role of aspartate-glutamate carrier in skeletal muscle and cancers

16:00 - 16:15 Petra Krenn: Regulation of lipolysis by phosphorylation

16:15 - 16:30 Melanie Korbelius: Consequences of defective lipolysis in the small intestine on lipid metabolism

16:30 - 17:00 Break

17:00 - 18:30 Session 2
chaired by: Christiane Klec & Vinay Sachdev

17:00 - 17:15 Meghana Somlapura: Analysis of the role of p62/Sequestosome-1 in α-synuclein mediated protein aggregation

17:15 - 17:30 Zahra Safari: The possible link between the microbiome composition of consomic mice and their different susceptibilities in development of steatosis under HFD

17:30 - 17:45 Madalina-Cristina Duta-Mare: Consequences of lysosomal acid lipase deficiency in macrophages metabolism

17:45 - 18:00 Isabelle Bina: Importance of ATGL in tumor development and progression

18:00 - 18:15 Tamara Tomin: Metabolic adaptation of cancer cells to the loss of ATGL and downregulation of lipolysis

18:15 - 18:30 Shirony Nicholson Puthen Veedu: Oncogene driven metabolic reprogramming

18:30 Dinner

19:30 - 20:30 Session 3
chaired by: Niroj Shrestha & Oleksandra Tiapko

19:30 - 20:30 KeyNote Lecture:
Jan Eggermont: P-type membrane transporters: from molecular machines to disease models
Laboratory of Cellular Transport Systems, Katholieke Universiteit Leuven, Leuven, Belgium

20:30 - 22:00 1^st Poster Session: Science & Wine

Stephanie Kolleritsch
H. Furkan Alkan
Petra Krenn
Melanie Korbelius
Meghana Somlapura
Zahra Safari
Madalina-Cristina Duta-Mare
Isabelle Bina
Tamara Tomin
Shirony Nicholson Puthen Veedu
Christiane Klec
Niroj Shrestha
Corina Madreiter-Sokolowski
Oleksandra Tiapko
Barbora Svobodova

Thursday, 29^th of October

08:30 - 10:00 Session 4
chaired by: Chaitanya Chakravarthi Gali & Pål William Wallace

08:30 - 08:45 Christiane Klec: Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca²⁺

08:45 - 09:00 Niroj Shrestha: Trimeric intracellular cation (TRIC) channels as a determinant of cellular calcium handling

09:00 - 10:00 KeyNote lecture:
Alexei Tepikin: ER-PM junctions, Ca²⁺ signalling and pancreatic diseases
The Physiological Laboratory, Department of Cellular and Molecular Physiology, University of Liverpool; Liverpool, UK

10:00 - 10:30 Break

10:30 - 12:00 Session 5
chaired by: Stephanie Kolleritsch & Lisa Maresch

10:30 - 10:45 Corina Madreiter-Sokolowski: Cancer cells prevent mitochondrial Ca²⁺ overload by modulation of MAM stability and UCP2/3 content

10:45 - 11:00 Oleksandra Tiapko: New strategies for optical control of lipid-gated TRPC channels

11:00 - 11:15 Barbora Svobodova: Identification of structural elements involved in lipid recognition and in lipid gating by Transient Receptor Potential Canonical channels

11:15 - 11:30 Katharina Huber: N-acetyltransferase 8-like (Nat8l) regulates cellular acetyl-CoA levels in brown adipocytes: Impact on energy metabolism, autophagy and histone acetylation

11:30 - 11:45 Christina Leopold: Consequences of lysosomal acid lipase deficiency on lipid and carbohydrate metabolism

11:45 - 12:00 Dina Hofer: Pex16 is a required factor for adipogenesis and white adipocyte lipid metabolism

12:00 - 13:00 Lunch

13:00 - 13:30 Session 6
chaired by: Isabelle Bina & Shirony Nicholson Puthen Veedu

13:00 - 13:15 Yidan Sun: Cholesterol homeostasis in fetoplacental endothelial cells is modulated by Gestational Diabetes Mellitus (GDM)

13:15 - 13:30 Katharina Kainz: A trans-species screen to identify pharmacological modifiers of mutant huntingtin toxicity

13:30 - 14:45 2^nd Poster Session

Katharina Huber
Christina Leopold
Dina Hofer
Yidan Sun
Katharina Kainz
Pål William Wallace
Helmut Pelzmann
Elham Fanaee-Danesh Jelena Tadic
Chaitanya Chakravarthi Gali
Wenmin Xia
Benjamin Gottschalk
Lisa Maresch
Lei Liu
Vinay Sachdev

14:45 - 15:00 MADL Tobias: Self-presentation
Institute of Molecular Biology & Biochemistry, MUG

15:00 - 16:00 PARALLEL MEETINGS OF THE FACULTY AND STUDENTS' FACULTY

16:30 Departure by bus

17:00 - 18:00 Guided Tour at the Flamberger Brewery

18:30 Joint Dinner at the Restaurant Harkamp

Friday, 30^th of October

08:30 - 09:45 Session 7
chaired by: H. Furkan Alkan & Katharina Kainz

08:30 - 08:45 Pål William Wallace: Polyesterase identified in the secretome of Pseudomonas Pseudoalcaligenes

08:45 - 09:00 Helmut Pelzmann: N-acetylaspartate (NAA) – a new metabolite in energy homeostasis

09:00 - 09:15 Elham Fanaee-Danesh: Bexarotene and Astaxanthin modulate cholesterol and amyloid-beta metabolism in an in vitro model of the blood-brain barrier

09:15 - 09:30 Jelena Tadic: The Hsp40 family member Ydj1 is required for Amyloid beta toxicity in a yeast model of Alzheimer’s disease

09:30 - 09:45 Chaitanya Chakravarthi Gali:Insulin and glucose modulate production and clearance of amyloid-β peptide in an in vitro model of the blood-brain barrier

09:45 - 10:15 Break

10:15 - 11:30 Session 8
chaired by: Tamara Tomin & Corina Madreiter-Sokolowski

10:15 - 10:30 Wenmin Xia: The role of Abhydrolase domain-containing 15 (Abhd15) in lipid metabolism

10:30 - 10:45 Benjamin Gottschalk: Application of structured illumination microscopy (SIM) in studying mitochondrial structure and function

10:45 - 11:00 Lisa Maresch: Cloning and characterization of an unknown Carboxylesterase (Ces2c) in the liver

11:00 - 11:15 Lei Liu: Molecular regulation of adrenal function by bile acids

11:15 - 11:30 Vinay Sachdev: DGAT1 alters intestinal cholesterol homeostasis via increased TICE

11:30 - 12:00 Break

12:00 - 13:00 Session 9
chaired by: Meghana Somlapura & Yidan Sun

12:00 - 13:00 KeyNote lecture:
Richard Lehner: Regulation of hepatic triglyceride storage and secretion by endoplasmic reticulum localized lipid hydrolases
Group on Molecular and Cell Biology of Lipids, Department of Pediatrics, University of Alberta, Edmonton, Canada

13:00 - 13:30 CONSORTIUM MEETING & Concluding Remarks

13:30 Lunch

Wednesday, 28^th of October
14:00 - 14:30	Opening & Welcome Notes by the Speaker and Students' speakers
	*Self-presentation of the new DK-MCD students:*
	H. Furkan Alkan Madalina-Cristina Duta-Mare Dina Hofer Lisa Maresch Zahra Safari Wenmin Xia
14:30 - 16:30	Session 1 chaired by: Christina Leopold & Helmut Pelzmann
14:30 - 15:30	KeyNote Lecture: Ira Goldberg: Glucose and white blood cells, unhappy together Division of Endocrinology, Diabetes and Metabolism, NYU Langone Medical Center, New York, USA
15:30 - 15:45	Stephanie Kolleritsch: The role of Perilipin 5 in cardiomyocyte energy catabolism
15:45 - 16:00	H. Furkan Alkan: Investigating the role of aspartate-glutamate carrier in skeletal muscle and cancers
16:00 - 16:15	Petra Krenn: Regulation of lipolysis by phosphorylation
16:15 - 16:30	Melanie Korbelius: Consequences of defective lipolysis in the small intestine on lipid metabolism
16:30 - 17:00	Break

17:00 - 18:30	Session 2 chaired by: Christiane Klec & Vinay Sachdev
17:00 - 17:15	Meghana Somlapura: Analysis of the role of p62/Sequestosome-1 in α-synuclein mediated protein aggregation
17:15 - 17:30	Zahra Safari: The possible link between the microbiome composition of consomic mice and their different susceptibilities in development of steatosis under HFD
17:30 - 17:45	Madalina-Cristina Duta-Mare: Consequences of lysosomal acid lipase deficiency in macrophages metabolism
17:45 - 18:00	Isabelle Bina: Importance of ATGL in tumor development and progression
18:00 - 18:15	Tamara Tomin: Metabolic adaptation of cancer cells to the loss of ATGL and downregulation of lipolysis
18:15 - 18:30	Shirony Nicholson Puthen Veedu: Oncogene driven metabolic reprogramming
18:30	Dinner
19:30 - 20:30	Session 3 chaired by: Niroj Shrestha & Oleksandra Tiapko
19:30 - 20:30	KeyNote Lecture: Jan Eggermont: P-type membrane transporters: from molecular machines to disease models Laboratory of Cellular Transport Systems, Katholieke Universiteit Leuven, Leuven, Belgium
20:30 - 22:00	1^st Poster Session: Science & Wine
	Stephanie Kolleritsch H. Furkan Alkan Petra Krenn Melanie Korbelius Meghana Somlapura Zahra Safari Madalina-Cristina Duta-Mare Isabelle Bina	Tamara Tomin Shirony Nicholson Puthen Veedu Christiane Klec Niroj Shrestha Corina Madreiter-Sokolowski Oleksandra Tiapko Barbora Svobodova

Thursday, 29^th of October
08:30 - 10:00	Session 4 chaired by: Chaitanya Chakravarthi Gali & Pål William Wallace
08:30 - 08:45	Christiane Klec: Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca²⁺
08:45 - 09:00	Niroj Shrestha: Trimeric intracellular cation (TRIC) channels as a determinant of cellular calcium handling
09:00 - 10:00	*KeyNote lecture:* Alexei Tepikin: ER-PM junctions, Ca²⁺ signalling and pancreatic diseases The Physiological Laboratory, Department of Cellular and Molecular Physiology, University of Liverpool; Liverpool, UK
10:00 - 10:30	Break
10:30 - 12:00	Session 5 chaired by: Stephanie Kolleritsch & Lisa Maresch
10:30 - 10:45	Corina Madreiter-Sokolowski: Cancer cells prevent mitochondrial Ca²⁺ overload by modulation of MAM stability and UCP2/3 content
10:45 - 11:00	Oleksandra Tiapko: New strategies for optical control of lipid-gated TRPC channels
11:00 - 11:15	Barbora Svobodova: Identification of structural elements involved in lipid recognition and in lipid gating by Transient Receptor Potential Canonical channels
11:15 - 11:30	Katharina Huber: N-acetyltransferase 8-like (Nat8l) regulates cellular acetyl-CoA levels in brown adipocytes: Impact on energy metabolism, autophagy and histone acetylation
11:30 - 11:45	Christina Leopold: Consequences of lysosomal acid lipase deficiency on lipid and carbohydrate metabolism
11:45 - 12:00	Dina Hofer: Pex16 is a required factor for adipogenesis and white adipocyte lipid metabolism
12:00 - 13:00	Lunch
13:00 - 13:30	Session 6 chaired by: Isabelle Bina & Shirony Nicholson Puthen Veedu
13:00 - 13:15	Yidan Sun: Cholesterol homeostasis in fetoplacental endothelial cells is modulated by Gestational Diabetes Mellitus (GDM)
13:15 - 13:30	Katharina Kainz: A trans-species screen to identify pharmacological modifiers of mutant huntingtin toxicity
13:30 - 14:45	2^nd Poster Session
	Katharina Huber Christina Leopold Dina Hofer Yidan Sun Katharina Kainz Pål William Wallace Helmut Pelzmann Elham Fanaee-Danesh	Jelena Tadic Chaitanya Chakravarthi Gali Wenmin Xia Benjamin Gottschalk Lisa Maresch Lei Liu Vinay Sachdev
14:45 - 15:00	MADL Tobias: Self-presentation Institute of Molecular Biology & Biochemistry, MUG
15:00 - 16:00	*PARALLEL MEETINGS OF THE FACULTY AND STUDENTS' FACULTY*
16:30	Departure by bus
17:00 - 18:00	Guided Tour at the Flamberger Brewery
18:30	Joint Dinner at the Restaurant Harkamp

Friday, 30^th of October
08:30 - 09:45	Session 7 chaired by: H. Furkan Alkan & Katharina Kainz
08:30 - 08:45	Pål William Wallace: Polyesterase identified in the secretome of Pseudomonas Pseudoalcaligenes
08:45 - 09:00	Helmut Pelzmann: N-acetylaspartate (NAA) – a new metabolite in energy homeostasis
09:00 - 09:15	Elham Fanaee-Danesh: Bexarotene and Astaxanthin modulate cholesterol and amyloid-beta metabolism in an in vitro model of the blood-brain barrier
09:15 - 09:30	Jelena Tadic: The Hsp40 family member Ydj1 is required for Amyloid beta toxicity in a yeast model of Alzheimer’s disease
09:30 - 09:45	Chaitanya Chakravarthi Gali:Insulin and glucose modulate production and clearance of amyloid-β peptide in an in vitro model of the blood-brain barrier
09:45 - 10:15	Break
10:15 - 11:30	Session 8 chaired by: Tamara Tomin & Corina Madreiter-Sokolowski
10:15 - 10:30	Wenmin Xia: The role of Abhydrolase domain-containing 15 (Abhd15) in lipid metabolism
10:30 - 10:45	Benjamin Gottschalk: Application of structured illumination microscopy (SIM) in studying mitochondrial structure and function
10:45 - 11:00	Lisa Maresch: Cloning and characterization of an unknown Carboxylesterase (Ces2c) in the liver
11:00 - 11:15	Lei Liu: Molecular regulation of adrenal function by bile acids
11:15 - 11:30	Vinay Sachdev: DGAT1 alters intestinal cholesterol homeostasis via increased TICE
11:30 - 12:00	Break
12:00 - 13:00	Session 9 chaired by: Meghana Somlapura & Yidan Sun
12:00 - 13:00	*KeyNote lecture:* Richard Lehner: Regulation of hepatic triglyceride storage and secretion by endoplasmic reticulum localized lipid hydrolases Group on Molecular and Cell Biology of Lipids, Department of Pediatrics, University of Alberta, Edmonton, Canada
13:00 - 13:30	*CONSORTIUM MEETING & Concluding Remarks*
13:30	Lunch