DK-MCD Retreat 2013

3^rd - 5^th October 2013
Seggau Castle

Thursday, 3^rd of October

14:00 - 14:30 Opening & Welcome Notes

14:30 - 15:45 Presentation: Group 1
chaired by: Helmut Pelzmann & Vinay Sachdev

14:30 - 14:45 Corina Madreiter: The ATP synthase controls mitochondrial Ca²⁺ uptake

14:45 - 15:00 Claire Jean-Quartier: New and old entities and their role in Ca²⁺ signaling within mitochondria

15:00 - 15:15 Pål William Wallace: Novel poly(ethylene terephthalate) degrading enzymes using activity based probes

15:15 - 15:30 Katarina Fritz: Glutamine-dependent regulation of β-oxidation in ATGL-KO tumor B-cells

15:30 - 15:45 Anita Kuldeep Mehta: Steatohepatitis-associated hepatocellular carcinoma: Evidence of a keratin-based disease

15:45 - 16:15 Break

16:15 - 17:30 Presentations: Group 2
chaired by: Claire Jean-Quartier & B. Shaymaa

16:15 - 16:30 Madeleine Goeritzer: TG-rich lipid droplet accumulation in CGI-58-/- macrophages leads to a pro-inflammatory macrophage phenotype and aggravates atherosclerosis susceptibility

16:30 - 16:45 Stefanie Schlager: ATGL deficiency and its impact on inflammatory cells

16:45 - 17:00 Vinay Sachdev: DGAT1 and its role in regulating intestinal cholesterol homeostasis

17:00 - 17:15 Helmut Pelzmann: N-acetyltransferase 8-like (Nat8l) regulates lipid metabolism in brown adipocytes

17:15 - 17:30 Manoja Brahma: Implications of fibroblast growth factor 21 (FGF21) on cardiac and whole-body energy metabolism

17:30 - 18:30 Poster Sessions of Groups 1 & 2

18:30 - 19:30 Dinner

20:00 - Get together

Friday, 4^th of October

09:30 - 11:00 Session 3

09:30 - 09:45 Peter Fickert: Molecular regulation of autophagy by bile acids in heart and kidney

09:45 - 10:00 Johannes Haybaeck: Translational regulation in metabolic associated liver cancer

10:00 - 10:15 Break

10:15 - 10:25 Gerald Hoefler/Dagmar Kratky: Short introduction to the hearing procedure

10:25 - 11:00 Introduction of Group 3

10:25 - 10:30 Wael Al Zoughbi: Adipose triglyceride lipase (ATGL) functions as a tumor suppressor protein

10:30 - 10:35 Jelena Belić: Analysis of plasma DNA using whole genome sequencing in patients with prostate cancer

10:35 - 10:40 Cornelia Sommer: Spermidine: A novel protector against neurodegeneration in D. melanogaster

10:40 - 10:45 Neelanjan Vishnu: Novel fluorescent reporters of ATP unveiled high dynamics of the energy carrier within the endoplasmic reticulum

10:45 - 10:50 Ariane Pessentheiner: N-acetyltransferase 8-like accelerates lipid turnover and increases energy expenditure in brown adipocytes

10:50 - 10:55 Anita Sahu: Phosphorylation of CGI-58 by protein kinase A

10:55 - 11:00 Michaela Lichtenegger: Towards understanding molecular function and pathophysiological role of the lipid-sensor channel TRPC3

11:00 - 13:00 Poster Sessions of Group 3

13:00 - 13:30 Lunch

13:30 - 15:30 Session 4

13:30 - 14:00 Introduction of Group 4

13:30 - 13:35 Anil Paul Chirackal Manavalan: Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in HDL genesis and remodeling at the blood brain barrier

13:35 - 13:40 Michaela Mueller: High dose ursodeoxycholic acid stimulates bile acid and cholesterol metabolism and alterations of lipid partitioning in morbidly obese patients

13:40 - 13:45 Chintan Navinchandra Koyani: Hypochlorite-modified low-density lipoprotein (HOCl-LDL): an in vivo occurring oxidative LDL modification promotes cardiomyocyte dysfunction

13:45 - 13:50 Nina Pollak: Perilipin 5 is a critical regulator of cardiac lipid mobilization

13:50 - 13:55 Pooja Lahiri: p62 acts as a molecular glue in the formation of cytoplasmic inclusions of liver (MDBs) in a mouse model of DDC induced hepatotoxicity

13:44 - 14:00 Nemanja Vujić: Increased atherosclerotic plaque formation in ApoE-deficient mice lacking monoacylglycerol lipase

14:00 - 16:00 Poster Sessions of Group 4

16:00 - 16:10 Break

16:10 - 17:00 FACULTY MEETING

17:30 Departure by bus

18:30 - 22:00 Joint Dinner at the Restaurant Jaglhof

Saturday, 5^th of October

09:00 - 11:00 Session 5
chaired by: Wael Al Zoughbi & Anita Mehta

09:00 - 10:00 KeyNote Lecture:
Paul Waring: Personalised Medicine – a pathologist's perspective
Department of Pathology, University of Melbourne, Australia

10:00 - 11:00 Presentations: Group 5

10:00 - 10:15 Jianfeng Huang: Reprogramming of hepatic lipid metabolism in tumor-associated cachexia and its potential influence on tumor growth

10:15 - 10:30 Ganapathy Shanmugam Paramasivan: The role of metabolic lipases in the pathogenesis of malignant tumours

10:30 - 10:45 Martina Zandl: ApoJ modulates amyloid-beta metabolism at the blood-brain barrier

10:45 - 11:00 Alexandra Kober-Macher: Modulation of ATP-binding cassette transporter G1, apolipoprotein M and AI- binding protein by LXR activation influence cholesterol transport at the blood brain barrier

11:00 - 11:30 Break

11:30 - 12:30 Presentations: Group 6
chaired by: Chintan Koyani & Neelanjan Vishnu

11:30 - 11:45 Sumitra Mohan: Development of acquired resistance to anti-EGFR therapy in colorectal cancer identified by whole-genome plasma DNA sequencing

11:45 - 12:00 Ge Jin: Atrial remodeling induced by chronic hypertension in a porcine model of hypertensive heart disease

12:00 - 12:15 Bernhard Doleschal: TRPC3 controls cardiac contractility and arrhythmogenesis by activity-dependent, dynamic interaction with NCX1

12:15 - 12:30 B. Shaymaa: On the mechanism(s) of mechanical stretch induced-NFAT nuclear translocation in HL-1 atrial myocytes

12:30 - 13:30 Lunch

13:30 - 14:30 Poster Sessions of Groups 5 & 6

14:30 - 15:00 CONSORTIUM MEETING

Thursday, 3^rd of October
14:00 - 14:30	Opening & Welcome Notes
14:30 - 15:45	Presentation: Group 1 chaired by: Helmut Pelzmann & Vinay Sachdev
14:30 - 14:45	Corina Madreiter: The ATP synthase controls mitochondrial Ca²⁺ uptake
14:45 - 15:00	Claire Jean-Quartier: New and old entities and their role in Ca²⁺ signaling within mitochondria
15:00 - 15:15	Pål William Wallace: Novel poly(ethylene terephthalate) degrading enzymes using activity based probes
15:15 - 15:30	Katarina Fritz: Glutamine-dependent regulation of β-oxidation in ATGL-KO tumor B-cells
15:30 - 15:45	Anita Kuldeep Mehta: Steatohepatitis-associated hepatocellular carcinoma: Evidence of a keratin-based disease
15:45 - 16:15	Break
16:15 - 17:30	Presentations: Group 2 chaired by: Claire Jean-Quartier & B. Shaymaa
16:15 - 16:30	Madeleine Goeritzer: TG-rich lipid droplet accumulation in CGI-58-/- macrophages leads to a pro-inflammatory macrophage phenotype and aggravates atherosclerosis susceptibility
16:30 - 16:45	Stefanie Schlager: ATGL deficiency and its impact on inflammatory cells
16:45 - 17:00	Vinay Sachdev: DGAT1 and its role in regulating intestinal cholesterol homeostasis
17:00 - 17:15	Helmut Pelzmann: N-acetyltransferase 8-like (Nat8l) regulates lipid metabolism in brown adipocytes
17:15 - 17:30	Manoja Brahma: Implications of fibroblast growth factor 21 (FGF21) on cardiac and whole-body energy metabolism
17:30 - 18:30	Poster Sessions of Groups 1 & 2
18:30 - 19:30	Dinner
20:00 -	Get together
Friday, 4^th of October
09:30 - 11:00	Session 3
09:30 - 09:45	Peter Fickert: Molecular regulation of autophagy by bile acids in heart and kidney
09:45 - 10:00	Johannes Haybaeck: Translational regulation in metabolic associated liver cancer
10:00 - 10:15	Break
10:15 - 10:25	Gerald Hoefler/Dagmar Kratky: Short introduction to the hearing procedure
10:25 - 11:00	Introduction of Group 3
10:25 - 10:30	Wael Al Zoughbi: Adipose triglyceride lipase (ATGL) functions as a tumor suppressor protein
10:30 - 10:35	Jelena Belić: Analysis of plasma DNA using whole genome sequencing in patients with prostate cancer
10:35 - 10:40	Cornelia Sommer: Spermidine: A novel protector against neurodegeneration in D. melanogaster
10:40 - 10:45	Neelanjan Vishnu: Novel fluorescent reporters of ATP unveiled high dynamics of the energy carrier within the endoplasmic reticulum
10:45 - 10:50	Ariane Pessentheiner: N-acetyltransferase 8-like accelerates lipid turnover and increases energy expenditure in brown adipocytes
10:50 - 10:55	Anita Sahu: Phosphorylation of CGI-58 by protein kinase A
10:55 - 11:00	Michaela Lichtenegger: Towards understanding molecular function and pathophysiological role of the lipid-sensor channel TRPC3
11:00 - 13:00	Poster Sessions of Group 3
13:00 - 13:30	Lunch
13:30 - 15:30	Session 4
13:30 - 14:00	Introduction of Group 4
13:30 - 13:35	Anil Paul Chirackal Manavalan: Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in HDL genesis and remodeling at the blood brain barrier
13:35 - 13:40	Michaela Mueller: High dose ursodeoxycholic acid stimulates bile acid and cholesterol metabolism and alterations of lipid partitioning in morbidly obese patients
13:40 - 13:45	Chintan Navinchandra Koyani: Hypochlorite-modified low-density lipoprotein (HOCl-LDL): an in vivo occurring oxidative LDL modification promotes cardiomyocyte dysfunction
13:45 - 13:50	Nina Pollak: Perilipin 5 is a critical regulator of cardiac lipid mobilization
13:50 - 13:55	Pooja Lahiri: p62 acts as a molecular glue in the formation of cytoplasmic inclusions of liver (MDBs) in a mouse model of DDC induced hepatotoxicity
13:44 - 14:00	Nemanja Vujić: Increased atherosclerotic plaque formation in ApoE-deficient mice lacking monoacylglycerol lipase
14:00 - 16:00	Poster Sessions of Group 4
16:00 - 16:10	Break
16:10 - 17:00	*FACULTY MEETING*
17:30	Departure by bus
18:30 - 22:00	Joint Dinner at the Restaurant Jaglhof
Saturday, 5^th of October
09:00 - 11:00	Session 5 chaired by: Wael Al Zoughbi & Anita Mehta
09:00 - 10:00	KeyNote Lecture: Paul Waring: Personalised Medicine – a pathologist's perspective Department of Pathology, University of Melbourne, Australia
10:00 - 11:00	Presentations: Group 5
10:00 - 10:15	Jianfeng Huang: Reprogramming of hepatic lipid metabolism in tumor-associated cachexia and its potential influence on tumor growth
10:15 - 10:30	Ganapathy Shanmugam Paramasivan: The role of metabolic lipases in the pathogenesis of malignant tumours
10:30 - 10:45	Martina Zandl: ApoJ modulates amyloid-beta metabolism at the blood-brain barrier
10:45 - 11:00	Alexandra Kober-Macher: Modulation of ATP-binding cassette transporter G1, apolipoprotein M and AI- binding protein by LXR activation influence cholesterol transport at the blood brain barrier
11:00 - 11:30	Break
11:30 - 12:30	Presentations: Group 6 chaired by: Chintan Koyani & Neelanjan Vishnu
11:30 - 11:45	Sumitra Mohan: Development of acquired resistance to anti-EGFR therapy in colorectal cancer identified by whole-genome plasma DNA sequencing
11:45 - 12:00	Ge Jin: Atrial remodeling induced by chronic hypertension in a porcine model of hypertensive heart disease
12:00 - 12:15	Bernhard Doleschal: TRPC3 controls cardiac contractility and arrhythmogenesis by activity-dependent, dynamic interaction with NCX1
12:15 - 12:30	B. Shaymaa: On the mechanism(s) of mechanical stretch induced-NFAT nuclear translocation in HL-1 atrial myocytes
12:30 - 13:30	Lunch
13:30 - 14:30	Poster Sessions of Groups 5 & 6
14:30 - 15:00	*CONSORTIUM MEETING*