Maria Mittelbrunn, Ph.D., from Centro de Biologia Molecular Severo Ochoa, Madrid, will talk about “Immunometabolism at the crossroad between inflammation and aging”: As in many other cells and tissues, cells of the immune system present mitochondrial decline with age. To investigate the consequences of the aging of the immune system, we have induced age-associated mitochondrial dysfunction prematurely in T cell. Targeting mitochondrial function in T cells recapitulates metabolic, phenotypic and functional features of aged T cells, including susceptibility to infections and premature inflammaging. We found that inducing age-associated mitochondrial decline in T lymphocytes, does not only cause an immunometabolic dysfunction that drives T cell senescence, but actually causes a general, body-wide deterioration of health with multiple aging-related features, including metabolic, musculoskeletal, cardiovascular and cognitive alterations, altogether resulting in premature death.
After the Flagship Lecture we invite all BioTechMed-Graz full members and associate members to a small buffet in the Rooftop Mensa from 6 to 9 p.m.
Please register for the event until May 20, 2024.
Childcare: BioTechMed-Graz is pleased to offer childcare for the Faculty Club from 4.30 p.m. until 8.00 p.m. in the Rooftop Mensa. If you need childcare, please register by May 17, 2024 at the latest.
For further inquiries, please contact the BioTechMed-Graz Coordination Office (office@biotechmedgraz.at, 0316/380 5020 or 5022).
